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Staff
Dr. Raman Sood is an associate investigator in the Translational and Functional Genomics Branch and director of the Zebrafish Core at the National Human Genome Research Institute. ​
… genomic events that lead to leukemogenesis, particularly acute myeloid leukemia involving mutations or chromosomal rearrangements of …
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… drug mercaptopurine (Purinethol) to patients with acute lymphoblastic leukemia. Some people have a genetic variant that interferes … For example, one of the treatment options for childhood acute lymphoblastic leukemia [cancer.gov] is stem cell …
Fact Sheets
A biological pathway is a series of actions among molecules in a cell that leads to a certain product or a change in the cell.
… designed to treat a blood cancer called chronic myeloid leukemia (CML). CML occurs because of a single genetic glitch …
Genetic Disorders
Familial Mediterranean Fever is an inherited disease, characterized by recurrent attacks of fever, inflammation, painful, swollen joints, and ankle rash.
… which are important in the immune response, and myeloid bone marrow precursors. Although the precise function … by the liver, that is only present during episodes of acute inflammation. Elevated albumin in the urine, which is …
Staff
Dr. Francis Collins is a senior investigator in Center for Precision Health Research.
… factor CBF beta/PEBP2 beta and a myosin heavy chain in acute myeloid leukemia . Science, 261, 1041-1044. 1993. Ballester R, …
For Patients and Families
​Pharmacogenomics combines the science of how drugs work, called pharmacology, with the science of the human genome, called genomics.​
… drug mercaptopurine (Purinethol) to patients with acute lymphoblastic leukemia. Some people have a genetic variant that interferes …
Staff
Dr. Peter McGuire is an investigator in NHGRI's Center for Precision Health Research.
… V., Rai, K. R., Ferrarini, M., et al. Chronic lymphocytic leukemia B cells can undergo somatic hypermutation and … Consortium, Summar, M. Infectious precipitants of acute hyperammonemia are associated with indicators of … P.M., Moran, T.M., Lee, H.S., Bequette, B.J., Diaz, G.A. Acute metabolic decompensation due to influenza in a mouse …
File
… ministudy@nih.gov National Human Genome Research Institute Acute Infection in Mitochondrial Disease Why are we doing … Research Nurse and study coordinator, at 301-451-9145. … Acute Infection in Mitochondrial Disease Flyer …
Profile
David Bodine, founder of the Hematopoiesis Section and chief of the Genetics and Molecular Biology Branch, advanced the fields of gene therapy and hematology in his 38 years at the NIH. Now, he plans to continue his contributions to science as an emeritus and through training the next generation of scientists.
… and ask, “Why does that one stem cell go nuts and become leukemia? Is it because of where it is, or is it because of … If you could then change the microenvironment and cure leukemia that way, it'd be a lot better than chemotherapy. … …
File
… blood cancers such as myelodysplastic syndrome or leukemia. Newsletter 2 Genomic research team New additions to … This meant restricting patients to those who are having acute interventions performed such as bone marrow transplant, … with R U N X1 to increase a person’s risk of developing leukemia or make their disease more severe? Are there …