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Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals. … lead to changes in physical traits, like eye color, and disease risk. Scientists use different technologies to do … diseases that affect humans. They edit the genomes of animals, like mice and zebrafish, because animals have …
Research at NHGRI
The Democratizing Education for Sickle Cell Disease Gene Therapy project utilizes a deliberative stakeholder-engagement approach to develop patient educational materials for sickle cell disease gene therapy.
… It is imperative that patients with sickle cell disease who are considering gene therapy fully understand the meaning and limitations of treatments so they can make an informed decision on … only. They are meant to promote your general understanding of gene therapy for sickle cell disease. We encourage you to …
Clinical Research
In the late 90’s and early 2000’s, scientists at the NIH highlighted an increased incidence of Parkinson disease among patients with GD and their families.
… Gaucher disease (GD) is a rare (autosomal recessive) genetic … byproduct stored in the lysosomes (recycling centers) of macrophages (clean-up cells of the immune system). In … J, Aflaki E, Sidransky E. Induced pluripotent stem cell models of lysosomal storage disorders. Dis Model Mech. …
News Release
Researchers at the NHGRI's Undiagnosed Disease Program have developed a new toolset for finding potential disease-causing gene variants in undiagnosed patients.
… Jeannine Mjoseth … Researchers with the National Institutes of Health Undiagnosed Disease Program (UDP) have developed a powerful new toolset … an individual's protein-coding genes. … The UDP is part of the Undiagnosed Diseases Network , which brings together …
News Release
NHGRI researchers seek help from people with Sickle Cell Disease to find the factors - environmental, social and genetic - that impact the severity of symptoms.
… Jeannine Mjoseth … People with sickle cell disease (SCD) can experience excruciating pain all over their bodies, kidney problems, higher risk of stroke and in rare cases, chronic leg ulcers. These and … oxygen delivery. Little is known about why the severity of these symptoms varies throughout the course of a lifetime, …
Educational Resources
Centrioles are paired barrel-shaped organelles located in the cytoplasm of animal cells near the nuclear envelope.
… paired barrel-shaped organelles located in the cytoplasm of animal cells near the nuclear envelope. … Cell Biology, … barrel-shaped organelles located in the cytoplasm of animal cells near the nuclear envelope. Centrioles play a …
The Genomics Landscape
In the September 2018 edition of The Genomics landscape, NHGRI Director Eric Green highlights five new educational videos that use poetry and dance.
… Bay Area) were open-ended discussions about the future of genomics. We continue to build on what we learn from each … place on Wednesday, September 26, 2018 at Morehouse School of Medicine in Atlanta, Georgia, beginning at 9:30 a.m. … the experience of a patient with a previously undiagnosed disease; through genome sequencing, doctors discover a …
For Teachers
Lesson plan based on an award-winning DNA from the Beginning website, an animated primer on the basics of DNA, genes and heredity.
… the Beginning website, an animated primer on the basics of DNA, genes and heredity. … The lesson plan is organized … on high school level activities under the Molecules of Genetics  section of the DNA from the Beginning  website. … Garrod propose as the cause for the phenotype of the disease of dark urine? How did George Beadle and Edward Tatum …
News Release
NHGRI researchers have released new educational materials to help the sickle cell disease community learn about gene therapies for the disease.
… emerging developments in gene therapies for sickle cell disease. … New educational materials to help the sickle cell … the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health. The Democratizing Education for Sickle Cell …
Clinical Research
A study to learn more about the role of viral infection and biomarkers of immunity in mitochondrial disease, utilizing new technology with Neoteryxâ„¢ fingerstick at-home sampling.
… A study to learn more about the role of viral infection and biomarkers of immunity in mitochondrial disease using new technology with Neoteryx ™ fingerstick …