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News Release
An ancient, sexually transmitted dog cancer may provide insights into human cancers because of the similarities in the dog and human immune systems.
… unhealthy dog tumor genomes, they found mutations in the tumors' genes that are involved in the ability of the host's … as dangerous outsiders. "The immune systems in dogs with tumors had lost the ability to recognize cancer cells because … it successfully for more than five thousand years." "Most tumors employ strategies to avoid destruction by the immune …
Genetic Disorders
Dercum disease is a rare condition that is characterized by multiple, painful fatty tumors that occur chiefly in post-menopausal, obese women of middle age.
… condition that is characterized by multiple, painful fatty tumors that occur chiefly in post-menopausal, obese women of … by multiple, painful fatty lipomas (benign, fatty tumors) that occur chiefly in post-menopausal, obese women of … condition that is characterized by multiple, painful fatty tumors that occur chiefly in post-menopausal, obese women of …
Media Availability
TCGA researchers have found that chromophobe renal cell carcinoma stems partly from gene alterations in the mitochondria, the cell's energy supplier.
… examining the entire genomes of 50 of the 66 ChRCC tumors studied, a high number for a rare cancer. The study … DNA. This led researchers to discover that ChRCC tumors favor a different energy-generating process than that … in the mitochondria, the cell's energy supplier. … Kidney tumors, chromophobe renal cell carcinoma, ChRCC, The Cancer …
News Release
NIH researchers have identified a striking signature in tumor DNA that occurs in five different types of cancer.
… around the gene known as ZNF154 that is unique to tumors." Dr. Elnitski is head of the Genomic Functional … identified the methylation mark using DNA taken from solid tumors. "No one in my group slept the night after that … methylation marks in the mixture. Knowing that tumors often shed DNA into the bloodstream, they calculated …
News Release
When it comes to Attention-Deficit/Hyperactivity Disorder (ADHD), genetics do make an impact.
… , NHGRI researchers examined people with ADHD to map brain connections, called white matter tracts, tied to the … of nerve fibers in and transfers information across the brain. With the help of magnetic resonance imaging (MRI) and … image processing, researchers can map connections in the brain and determine whether there are subtle disruptions to …
Educational Resources
Autism is a developmental brain disorder characterized by impaired social interactions, communication problems, and repetitive behaviors.
… Autism … Autism is a developmental brain disorder characterized by impaired social interactions, … Developmental Disorder … Autism is a condition related to brain development that can cause significant social, … and to varying degrees. … Autism is a developmental brain disorder characterized by impaired social interactions, …
Media Availability
Researchers have created a promising new method to accurately and more comprehensively analyze and interpret DNA sequence information from cancer patients.
News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… genomics study of clear cell endometrial cancer (CCEC) tumors to date, National Human Genome Research Institute … also demonstrated that the mutation profiles of CCEC tumors are sometimes similar to other types of uterine … at identifying genes that are mutated (changed) in the tumors of patients with clinically aggressive forms of …
Genetic Disorders
Prostate cancer is a disease where certain cells in the prostate become abnormal and multiply to form a tumor.
Staff
Dr. Laura Elnitski is a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research Institute.
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… DNA methylation in a variety of gynecological tissues and tumors (from top to bottom, respectively) (Sánchez-Vega et … whose epigenetic state is commonly altered in epithelial tumors from 15 distinct types of cancer, providing a … she is pursuing the role of the methylator phenotype in tumors, characterized by extensive methylation of the tumor …