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News Release
NHGRI researchers have released new educational materials to help the sickle cell disease community learn about gene therapies for the disease.
… emerging developments in gene therapies for sickle cell disease. … New educational materials to help the sickle cell disease community learn about gene therapies for the … are now available from researchers at the National Human Genome Research Institute (NHGRI), part of the National …
Educational Resources
BRCA1 and BRCA2 are the first two genes found to be associated with inherited forms of breast cancer.
… found to be associated with inherited forms of breast cancer. … Breast Cancer, Prostate Cancer, Genetic Mutation, Genes, DNA Repair, … act as tumor suppressors, meaning they help to regulate cell division. Most people have two active copies of these …
Educational Resources
Sickle cell disease is a hereditary disease seen most often among people of African ancestry.
… Sickle Cell Disease … Sickle cell disease is a hereditary disease seen most often among … Gene, Inherited, Mutation, Protein, Recessive … Sickle cell disease is a hereditary disease seen most often among …
Policy Issues
Genome editing is currently being applied to research on cancer, mental health, rare diseases, and many other disease areas.
… Genome editing is currently being applied to research on … and somatic  therapy. Germline therapies can alter many cell types but by definition they also change genes in …
News Release
In a study published in the journal Science, collaborators at NHGRI, the National University of Ireland, Galway, and the Whitney Laboratory for Marine Bioscience at the University of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly.
… Hydractinia  is dissimilar to humans physiologically, its genome contains a surprisingly large number of genes. Piwi1-positive spermatogonia are shown in yellow; cell nuclei are in turquoise. Germ cell induction and all stages of gametogenesis can be …
The Genomics Landscape
In the June 2020 edition of The Genomics Landscape, NHGRI Director Eric Green details NHGRI's new Diversity in Genomics Workforce Initiative.
… up to the 30th anniversary of the launch of the Human Genome Project in October 2020. I encourage you to check out … gene-editing therapy to cure an individual with sickle cell disease. This has been heralded as a landmark moment for … and health disparities lecture – Subtype-specific breast cancer risk in highly indigenous Latin American women, Laura …
News Release
NHGRI researchers asked patients, parents and physicians in the sickle cell disease community (SCD) what they wanted and needed to know about genome editing to make informed decisions about participating in genome-editing clinical trials.
… … As public interest and expanded research in human genome editing grows, many questions remain about ethical, … asked patients, parents and physicians in the sickle cell disease community what they wanted and needed to know … treatments, which appear to provide a potential for sickle cell, are among the most widely publicized medical advances …
News Release
NIH researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy.
… have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted … gene therapy for humans. Researchers at the National Human Genome Research Institute (NHGRI), part of NIH, published … to deliver the corrected gene to a specific point in the cell's DNA. AAVs are small viruses that infect humans but do …
The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… agents and their effects on the development of a cell’s normal state. In addition, LINCS developed a resource … broader biomedical enterprise. …  NHGRI and the National Cancer Institute (NCI) are partnering to fund grants totaling … the status of the evolutionary synthesis after the Human Genome Project; and recent work in human genomic variation. … …
Fact Sheet
Currently, there are different gene therapy approaches available through clinical trials.
… Hemoglobin types and sickle cell disease  Your red blood cells contain hemoglobin , a … oxygen to your body’s organs and tissues. Every red blood cell contains thousands of hemoglobin molecules.  The genes … to instead make hemoglobin A. For individuals with sickle cell disease, a small amount of HbF continues to be produced …