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Research Funding
The Encyclopedia of DNA Elements (ENCODE) Pilot Project launched in September 2003 to identify all functional elements in the human genome sequence.
… genome was announced by the International Human Genome Sequencing Consortium ( Finishing the euchromatic sequence of … transcriptional regulatory sequences and determinants of chromosome structure and function, such as origins of … from whole genome shotgun assemblies or obtained by direct sequencing of BAC clones, are submitted and updated …
The Genomics Landscape
In the October 6, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., celebrates the 25th anniversary of the NIH Intramural Sequencing Center (NISC). a well-respected and highly used large-scale DNA sequencing center that exemplifies the evolution of the field of genomics and the ever-increasing abilities to produce prodigious amounts of genomic data.
… sequence to public databases weekly, as large-scale DNA sequencing had advanced substantially. At that time, it … Eric Green, proposed the idea of establishing a DNA sequencing center at NIH to Francis Collins and Jeff Trent … joined forces with NHGRI to establish the NIH Intramural Sequencing Center (NISC) in the fall of 1997. . . and the …
News Release
NHGRI will fund a set of genome sequencing and analysis centers whose research will focus on understanding the genomic bases of common and rare human diseases.
… National Institutes of Health will fund a set of genome sequencing and analysis centers whose research will focus on … for Common Disease Genomics (CCDG), which will use genome sequencing to explore the genomic contributions to common … cystic fibrosis and muscular dystrophy. "Advances in DNA sequencing are creating tremendous new opportunities for …
Research Funding
A collaborative large-scale genome sequencing effort to identify rare risk and protective variants contributing to multiple common disease phenotypes.
… Genomics (CCDG) are a collaborative large-scale genome sequencing effort to comprehensively identify rare risk and … Common Disease Genomics … Collaborative large-scale genome sequencing effort to identify rare risk and protective … Variants, Genetic Risk, Common Disease, Rare Disease, Dna Sequencing, Dna Sequencing Technology … A collaborative …
Educational Resources
Gene amplification is an increase in the number of copies of a gene sequence.
Talking Glossary
An inversion in a chromosome occurs when a segment breaks off and reattaches within the same chromosome, but in reverse orientation.
… Inversion … An inversion in a chromosome occurs when a segment breaks off and reattaches within the same chromosome, but in reverse orientation. … An inversion in a chromosome occurs when a segment breaks off and reattaches …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… They've combined several technologies, including DNA sequencing, and have gained insights into how genomic …
About Genomics
In 2003, an accurate and complete human genome sequence was finished two years ahead of schedule and at a cost less than the original estimated budget.
… the project took on a wide range of other goals, from sequencing the genomes of model organisms to developing new … is known. Because each is unique, STSs are helpful in chromosome placement of mapping and sequencing data from many different laboratories. STSs serve …
The Genomics Landscape
In the February 12, 2021 edition of The Genomics Landscape, Dr. Eric Green talks about the 20-year anniversary of the publications that reported the draft human genome sequence.
… the 1980s discussing the desirability and feasibility of sequencing the human genome, to the U.S. Department of … biomedical research. The International Human Genome Sequencing Consortium committed to rapid data sharing , … promoted open science. Later, the development of new DNA sequencing technologies and the resulting reductions in the …
Genetic Disorders
Turner syndrome is a chromosomal condition that alters development in females.
… syndrome is a chromosomal condition related to the X chromosome . [ghr.nlm.nih.gov] Researchers have not yet determined which genes on the X chromosome are responsible for most signs and symptoms of … (This is written as XX.) Males have an X and a Y chromosome (written as XY). The two sex chromosomes help a …