Search Results
The Genomics Landscape
NHGRI medical genetics training programs provide an array of education opportunities
… Equity Fellowship Program in partnership with the Food and Drug Administration’s (FDA’s) Office of Minority Health and … medical product development processes that facilitate the delivery of drugs, biologics, and devices from the bench to …
News Release
The U.S. National Institutes of Health (NIH) has long invested in basic genetics and genomics research, clinical trials, as well as translational medicine and social science studies, to advance our understanding of this widespread illness to help develop effective therapies.
… Today, the U.S. Food and Drug Administration (FDA) approved two gene therapies for the …
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… providing leadership and resources to facilitate the delivery of high-quality clinical and laboratory medical … risk assessments and paternity and forensic computations. DELIVERY OF GENETIC AND GENOMIC HEALTH CARE The delivery of genetic and genomic health care often requires …
Office of Genomic Data Science
NHGRI is committed to increase the availability of educational and research opportunities in computational genomics and data science (CGDS).
… burdened by disparities in health status and health care delivery, including racial and ethnic minority groups, …
Staff
William J. Pavan, Ph.D. is the chief of NHGRI's Genetic Disease Research Branch.
… as well as provide animal models for future studies of drug intervention. Dr. Pavan’s group continues to identify … adeno-associated virus vector types (AAV9) and also varied delivery methods to NPC1 mouse mutants, then evaluating …
Explainer
Appropriate use of population descriptors in research is a critical scientific issue that is important for advancing genomic science and improving healthcare across human populations.
… ; examining the impact of racial bias in health service delivery 17 and monitoring diversity, equity and inclusion …
For Patients and Families
​Clinical research is research conducted with human subjects, or material of human origin, in which the researcher directly interacts with human subjects.
… phases: In Phase I clinical trials, researchers test a new drug or treatment for the first time in a small group of … side effects. In Phase II clinical trials, the study drug or treatment is given to a larger group of people (about … patients with the particular disease, to see if the drug or treatment is effective, and to further evaluate its …
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… hub and spoke design • Focus on real -world health care delivery • Coordinating Center – Logistics planning – Support … PGx testing for antiplatelet therapy • Reduce adverse drug side effects Diversity in ancestry 72,147 IGNITE …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… you could figure out patterns of toxicity of potential new drug compounds by looking at cellular responses and finding … responses to drugs was more accurate than conventional drug-potency tests. This recognition may point the way toward … and diseased human cells. Dr. Sorger hopes that future drug developers will be able to perform computations on LINCS …
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… account a person's genetic information regarding specific drug receptors and how drugs are transported and metabolized … goal of pharmacogenetics is to create an individualized drug therapy that allows for the best choice and dose of drugs. One example is the breast cancer drug trastuzumab (Herceptin). This therapy works only for …