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Genetic Disorders
Severe Combined Immunodeficiency is a severe, genetic condition of the immune system.
… evaluating insertion profiles of standard and novel gene delivery methods. A goal of this work is to find ways to …
News Release
NIH scientists proposed a new approach for finding ways to impede or halt cancer's spread: transgenic zebrafish as a live animal model of metastasis.
… Such high-throughput screening has identified thousands of drug candidates over the past 10 years but has resulted in …
File
… and through descriptions of best practices for the delivery of genomic medicine. 2) Education: Provide education … ACMG has entered into an agreement with the US Food and Drug AdministrationÕs Center for Devices and Radiologic … genetic services across the lifespan and across healthcare delivery systems. At the time of the rollout of the ACA and …
Fact Sheet
mRNA vaccines inject cells with instructions to generate a protein that is normally found on the surface of SARS-CoV-2, the virus that causes COVID-19.
… authorized for use in the United States by the Food and Drug Administration (FDA) are mRNA vaccines. … Fact Sheet … …
News Release
The Genetics/Genomics Competency Center now includes a new section on pharmacogenetics and pharmacogenomics.
… genetic makeup, or genome, to choose the drugs and drug doses that are likely to work best for that particular … advanced resources for pharmacists implementing specific drug/gene pairs, such as CPIC guidelines, are also available. …
Genetic Disorders
Crohn's disease is a chronic inflammatory disorder of the bowel, usually diagnosed in people between the ages of 20 - 30.
… such as abdominal pain, diarrhea and rectal bleeding. Drug therapy for Crohn's disease includes: Anti-inflammation … system suprressors, such as 6-mercaptopurine or a related drug, azothioprine. Infliximab (Remicade), a drug that is the first of a group of medications that blocks …
News Release
20 papers published online in 2014 highlight research on DNA biorepositories and electronic medical records to better understand the genomics of disease.
… curtail a gene's activities. Researchers identified two drug-metabolizing variants tied to three TPMT alleles. The …
News Release
A new phase of the IGNITE Network will conduct clinical trials of genomic medicine interventions.
… – two conditions where finding safe and effective drug treatments have been difficult. Because there are few … makeup helps determine how they will respond to certain drug treatments. In pharmacogenomics, information about a … makeup helps determine how they will respond to certain drug treatments. These projects build upon the first phase of …
Genetic Disorders
Huntington's disease is an inherited neurological illness causing involuntary movements, severe emotional disturbance and cognitive decline.
… from generation to generation. Clinical trials of drugs: Drug testing includes classes of drugs that control symptoms, … found an effective way to slow or prevent the disease. The drug used by UC Irvine researchers to prevent the cell death … cancer in humans. This could speed up human trials of the drug in Huntington's disease patients. … The discovery of the …
The Genomics Landscape
In the January 2018 edition of The Genomics Landscape, NHGRI Director Eric Green features the NIH Intramural Sequencing Center.
… to genomics: " pinpoint gene editing ," " a cancer drug's broad swipe ," and " gene therapy triumph ."  Nature's …