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News Release
The Genetics/Genomics Competency Center now includes a new section on pharmacogenetics and pharmacogenomics.
… genetic makeup, or genome, to choose the drugs and drug doses that are likely to work best for that particular … advanced resources for pharmacists implementing specific drug/gene pairs, such as CPIC guidelines, are also available. …
Genetic Disorders
Crohn's disease is a chronic inflammatory disorder of the bowel, usually diagnosed in people between the ages of 20 - 30.
… such as abdominal pain, diarrhea and rectal bleeding. Drug therapy for Crohn's disease includes: Anti-inflammation … system suprressors, such as 6-mercaptopurine or a related drug, azothioprine. Infliximab (Remicade), a drug that is the first of a group of medications that blocks …
Research Funding
The Knockout Mouse Phenotyping Project (KOMP2) collaborates with the International Mouse Phenotyping Consortium (IMPC) to knockout and characterize all protein-coding genes in the mouse genome.
News Release
NHGRI hosted a CRISPR "Ask Me Anything" with Jennifer Doudna, Ph.D., reaching 10.5 million people worldwide.
News Release
20 papers published online in 2014 highlight research on DNA biorepositories and electronic medical records to better understand the genomics of disease.
… curtail a gene's activities. Researchers identified two drug-metabolizing variants tied to three TPMT alleles. The …
News Release
A new phase of the IGNITE Network will conduct clinical trials of genomic medicine interventions.
… – two conditions where finding safe and effective drug treatments have been difficult. Because there are few … makeup helps determine how they will respond to certain drug treatments. In pharmacogenomics, information about a … makeup helps determine how they will respond to certain drug treatments. These projects build upon the first phase of …
Genetic Disorders
Huntington's disease is an inherited neurological illness causing involuntary movements, severe emotional disturbance and cognitive decline.
… from generation to generation. Clinical trials of drugs: Drug testing includes classes of drugs that control symptoms, … found an effective way to slow or prevent the disease. The drug used by UC Irvine researchers to prevent the cell death … cancer in humans. This could speed up human trials of the drug in Huntington's disease patients. … The discovery of the …
Fact Sheet
mRNA vaccines inject cells with instructions to generate a protein that is normally found on the surface of SARS-CoV-2, the virus that causes COVID-19.
… authorized for use in the United States by the Food and Drug Administration (FDA) are mRNA vaccines. … Fact Sheet … …
News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
File
… A. Malaria Resurgence After Significant Reduction by Mass Drug Administration on Ngodhe Island, Kenya. Sci Rep Nature. … by Assessing Dextromethorphan O - Demethylation Activity. Drug Metab Pharmacokinet. , 2020 Feb; 35(1):89 -101. 161. … Mechanisms of the Genes That Have the Potential to Affect Drug Resistance. 2020. (TUBITAK, Submitted). 80. Guio H (PI), …