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News Release
The Telomere-to-Telomere (T2T) Consortium has generated the first truly complete sequence of a human Y chromosome - the final human chromosome to be fully sequenced.
… New sequence reveals genomic factors in fertility, including sperm production. … An … genomic features with implications for fertility, such as factors in sperm production. The study, led by the … While these chromosomes play a central role, the factors involved in human sexual development are spread …
Clinical Research
GENE-FORECAST® is developing a community cohort and resource for defining the significance of ancestry-related genomic variation in African-Americans.
… The Genomics, Environmental Factors and the Social Determinants of Cardiovascular Disease … and the exposome of social determinants and environmental factors that influence the pathogenesis of CVD in AA. The … common or ancestry-related DNA variants and CVD risk factors (e.g. hypertension) and phenotypes (e.g. coronary …
The Genomics Landscape
In the July 2023 edition of The Genomics Landscape, NHGRI Director Eric Green describes the evolution of the NHGRI Intramural Research program over the last three decades talks about its future in conducting truly exceptional basic, translational, and clinical genomics research.
… months.  All the best,   … Multifactorial profiling of epigenetic landscapes at single-cell resolution using … aiming to understand traits informed by many genetic factors and disease development.  This research was funded …
Clinical Research
The INSIGHTS study is exploring sickle cell disease in adults.
… exploring sickle cell disease in adults by looking at many factors, including genomic, microbial, physical and social … influences. … The goal of this study is to learn how these factors influence the onset and development of sickle cell … to sickle cell disease with a special emphasis on the factors that cause a subset of SCD patients to develop leg …
Event
The Advances in Genomic Technology Development (AGTD) 2022 Annual Meeting was hosted by the Technology Development Coordinating Center (TDCC) from July 12-14, 2022 at The Jackson Laboratory (Farmington, CT).
… for Highly Parallel Analysis of Variation in Transcription Factors and their DNA Binding Sites Shubham Khetan, … in situ Method to Study the Combinatorial Code of Epigenetic Marks in Single Cells Yanbo Chen Yale University … discussed genomic technologies that include nanopore and epigenetic sequencing as well as multi-omic analyses of …
News Release
NHGRI researchers and colleagues are calling for health disparities research that focuses on the microbiome.
… be a two-way street, with the biological and environmental factors influencing each other, according to the perspective … the socioeconomic, psychosocial, cultural and behavioral factors in people of diverse ancestry, according to the … microbiome interacts with social and environmental factors," said Vence L. Bonham, Jr., J.D., perspective …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… response to perturbing agents - such as drugs and genetic factors - that are potentially disruptive to cells. LINCS … cellular model systems. Cellular phosphor-signaling and epigenetic systems are involved in a growing number of …
Staff
Dr. Meeks is a Research Fellow at the Center for Research on Genomics and Global Health.
… which she studies the interrelationships between lifestyle factors, cytokines, genetic variants, and epigenetic biomarkers in type 2 diabetes among …
Staff
Dr. Laura Elnitski is a senior investigator in the Translational and Functional Genomics Branch at the National Human Genome Research Institute.
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… promoters, enhancers, silencers, splicing elements and epigenetic regulators. She received an Outstanding Research … the most intriguing components of gene regulation is the epigenetic code, which influences gene expression from its … the DNA sequence. Dr. Elnitski's group is studying altered epigenetic patterns of cancer samples to identify genomic …
Staff
Dr. Susan Persky is an associate investigator in the Social and Behavioral Research Branch at the National Human Genome Research Institute.
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… patients and providers (e.g., racial concordance). These factors are of particular importance when communicating about … She also explores how beliefs about genetic causal factors in health conditions influence health identity, … when communicating to parents about their child’s risk factors, a gene-environment interaction approach may be …