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The Genomics Landscape
In the April 2021 issue of the Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D. talks about the NIH UNITE program's goal to end structural racism in biomedical research.
… considering the importance of social and environmental factors that influence human health (and the interactions … human health is affected by both genomic and non-genomic factors — trying to understand what these factors are and how … p.m. to 4:30 p.m. Prediction: The general features of the epigenetic landscape and transcriptional output will be …
Research Funding
The centers study in innovative ways to address important ethical, legal, and social issues related to advances in genomics.
… and evolving ELSI issues is critical. All of these factors contribute to a need for new and more innovative … risks associated with genomic information, examining factors that influence how people perceive such risks. The … center conducted research on the ethical, legal and social factors that influence the translation of genetic information …
Staff
Dr. Philip Shaw is an investigator in the Social and Behavioral Research Branch at the National Human Genome Research Institute.
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… His main interest is in the genetic and environmental factors that influence the development of brain and behavior. … examines the interplay of genomic and environmental factors in shaping the developmental trajectories of brain … S, Hansen N, Elnitski, L & Shaw P. Neuroanatomic, epigenetic, and genetic differences in monozygotic twins …
15 Ways Genomics Influences Our World
We are learning how our genomes serve as blueprints for life.
Educational Resources
In genomic imprinting the ability of a gene to be expressed depends upon the sex of the parent who passed on the gene.
… itself. Instead, gene expression is silenced by the epigenetic addition of chemical tags to the DNA during egg or sperm formation. Epigenetic tags on imprinted genes usually stay in place for …
Profile
Dr. Joan Bailey-Wilson, who retired in September 2022, looks back on her 42-year career as a scientist and reflects on the rapid growth of the genomics field.
… if you accounted for smoking and known environmental risk factors, there was still increased familial risk, which was … methods that would allow us to include environmental risk factors in our genetic analyses. Since then, we've identified … contributed to these cancers, rather than environmental factors or by chance. The group quickly embraced new …
For Teachers
The Your Genome & You infographic introduces the basics of genetics and genomics, and how the science impacts our lives.
… by demonstrating the outcome of an environmentally induced epigenetic change through animation. … Toolkit … Resources … …
Health
A polygenic risk score is one way by which people can learn what their risk of developing a disease is, based on the total number of genomics variants related to the disease.
… many of their genes, frequently coupled with environmental factors. Researchers are studying these changes to understand … that are influenced by multiple genes and environmental factors. Many diseases fall on a spectrum between these two …
About Genomics
Resources for understanding the first complete, gapless sequence of a human genome.
… 376. Doi: 10.1126/science.abj6987 (2022) Gershman et al. Epigenetic patterns in a complete human genome . Science … al. From telomere to telomere: The transcriptional and epigenetic state of human repeat elements . Science  376. … (2022) Altemose et al. Complete genomic and epigenetic maps of human centromeres . Science 376. Doi: …
About Genomics
Resources for understanding the first truly complete sequence of the Y chromosome, the final human chromosome to be fully sequenced.
… genetic features with implications for fertility, such as factors in sperm production. Learn more about this … human #YChromosome sequence! This sequence reveals genetic factors with implications for fertility. …