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The Genomics Landscape
In the January 2020 edition of The Genomics Landscape, NHGRI Director Eric Green highlights the newly developed polygenic risk scores webpage, which provides graphical and textual information about polygenic risk scores, describes polygenic traits, introduces how polygenic risk scores can be calculated, and explains how such scores can be interpreted.
News Release
NIH researchers have successfully identified differences in gene activity in the brains of people with attention deficit hyperactivity disorder (ADHD). The study, led by scientists at the National Human Genome Research Institute (NHGRI), found that individuals diagnosed with ADHD had differences in genes that code for known chemicals that brain cells use to communicate.
… specific genes are turned on or off, also known as gene expression . They studied two connected brain regions … closer to understanding how genomic differences alter gene expression in the brain and contribute to ADHD symptoms. With … types of genomic studies are pointing towards the expression of the same genes,” said Gustavo Sudre, Ph.D., …
Staff
Dr. Paul Liu is a senior investigator in NHGRI's Translational and Functional Genomics Branch.
… respectively) that form a dimer for DNA binding and gene expression regulation, are frequent targets of such … Liu PP. Zebrafish homolog of the leukemia gene CBFB : its expression during embryogenesis and its relationship to scl … of Ro5-3335 as an inhibitor of CBF leukemia through quantitative high-throughput screen against RUNX1-CBFß …
News Release
NIH and Inova Health are launching The Genomic Ascertainment Cohort, a pilot project that will examine gene and gene variant influence on phenotypes.
Educational Resources
An exon is the portion of a gene that codes for amino acids.
… that codes for amino acids. … Intron, DNA Sequence, DNA Expression, RNA, Genes, Genetic Code … An exon is a region of …
Educational Resources
Evolution is the process by which organisms change over time.
… over time. … Genetic Mutation, Genetic Variation, Gene Expression, Charles Darwin, The Origin Of Species, Genes … …
News Release
NHGRI researchers collaborated with physicians and medical geneticists worldwide to create the Atlas of Human Malformation Syndromes in Diverse Populations.
Staff
Dr. Simona Volpi is a program director in the Division of Genomic Medicine at the National Human Genome Research Institute.
… grants and contracts related to the Genotype-Tissue Expression (GTEx) Project as well as the newly established … … Simona Volpi, common diseases, Genotype-Tissue Expression Project (GTEx), NIH Common Fund … Dr. Simona Volpi …
Educational Resources
Recombinant DNA Technology is a technology that uses enzymes to cut and paste together DNA sequences of interest.
… … Cell, Deoxyribonucleic Acid (DNA), Enzyme, Gene Expression, Restriction Enzyme, Vector … Recombinant DNA …
Educational Resources
Non-coding DNA corresponds to the portions of an organism’s genome that do not code for amino acids, the building blocks of proteins.
… the building blocks of proteins. … DNA Sequence, Gene Expression, Chromosome, Non-coding DNA, Junk DNA, Genetic … serve functional roles, such as in the regulation of gene expression, while other areas of non-coding DNA have no known …