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News Release
Researchers analyzing human, fly, and worm genomes have found these species have key genomic processes in common, reflecting their shared ancestry.
… Of DNA Elements (modENCODE) Consortium studied how gene expression patterns and regulatory proteins that help … genes and regulatory elements that control gene expression. The current work builds on initial catalogs … (or readouts) in a genome. They used large amounts of gene expression data generated in the ENCODE and modENCODE …
Educational Resources
A genome-wide association study (GWAS) is an approach used in genetics research to associate specific genetic variations with particular diseases.
… … Genome-Wide Association Studies, GWAS, DNA, Genome, Gene Expression, Gene Variation, Personalized Medicine, Gene … associated with a risk for a disease or a particular trait. The method involves surveying the genomes of many … occur more frequently in those with a specific disease or trait compared to those without the disease or trait. Once …
Educational Resources
A promoter is a sequence of DNA needed to turn a gene on or off.
… or off. … Deoxyribonucleic Acid (DNA), Enzyme, Gene, Gene Expression, Gene Regulation, Messenger RNA (mRNA), …
Staff
Dr. Elise Feingold is a scientific program manager in NHGRI's Division of Genome Sciences.
… 1992 as a program director focused on gene discovery, gene expression and functional genomics. Since 2019, Dr. Feingold … implications for the control of gamma-globin gene expression in man . Proc Natl Acad Sci U S A , … Excellence in Genomic Science (CEGS), gene discovery, gene expression, functional genomics … Dr. Elise Feingold is a …
The Genomics Landscape
In the October 1, 2020 edition of The Genomics Landscape, Dr. Eric Green reflects on the last 30 years since the launch of the Human Genome Project.
… 30 years ago. …  Researchers from the Genotype-Tissue Expression Project (GTEx) consortium, an NIH Common Fund … gene expression produced to date. The studies focus on quantitative trait loci (QTL), specifically associations between known …
Educational Resources
Translation is the process of translating the sequence of a messenger RNA (mRNA) molecule to a sequence of amino acids during protein synthesis.
… … Transcription, Base Pair, Cell, Cytoplasm, Gene, Gene Expression, Genetic Code, Messenger RNA (mRNA), Protein, …
Fact Sheets
Genome-wide association studies involve scanning markers across the genomes of many people to find genetic variations associated with a particular disease​.
… … Genome-Wide Association Studies, GWAS, DNA, Genome, Gene Expression, Gene Variation, Personalized Medicine, Gene …
Educational Resources
Transcription is the process of making an RNA copy of a gene sequence.
… … Cell, Cytoplasm, Deoxyribonucleic Acid (DNA), Gene, Gene Expression, Messenger RNA (mRNA), Nuclear Membrane, Nucleus, …
The Genomics Landscape
In the August 6, 2020 edition of The Genomics Landscape, Dr. Eric Green talks about NHGRI's completion of the third phase of the ENCODE Project and how it reveals the most extensive catalog to date of candidate functional elements that may regulate the genes in the human and mouse genomes.
… to DNA, and how RNA molecules interact to regulate gene expression. The results reported in the ENCODE 3 publications … outside of protein-coding regions can influence gene expression. The ENCODE Project began in 2003, shortly after … a new initiative, the Developmental Genotype-Tissue Expression ( dGTEx ) Project. The goal of dGTEx is to …
About Genomics
In 2003, an accurate and complete human genome sequence was finished two years ahead of schedule and at a cost less than the original estimated budget.
… Human Genome Sequencing, Long-range Planning, Gene Expression, Sequence Variations, Phenotypes, Large-scale …