Search Results
Genetic Disorders
Autosomal Dominant Polycystic Kidney Disease is a genetic disorder characterized by the growth of numerous cysts in both kidneys.
… vessels (vascular system) such as high blood pressure (hypertension) intracranial and aortic aneurysms, heart valve defects , and abdominal wall hernias. Hypertension is the most common problem as a result of ADPKD. …
Clinical Research
GENE-FORECAST® is developing a community cohort and resource for defining the significance of ancestry-related genomic variation in African-Americans.
… ancestry-related DNA variants and CVD risk factors (e.g. hypertension) and phenotypes (e.g. coronary artery … proportion of AA with CVD risk factors such as obesity and hypertension that predispose to the eventual clinical signs …
Research at NHGRI
The Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch studies the genomic and social determinants of complex diseases.
… distributed by ethnicity and geography (e.g., diabetes, hypertension, heart and kidney disease, scleroderma and …
Profile
Dr. Hanchard talks about his journey into genetics research, his collaborations with international researchers, and the importance of determination in science.
… genomics to understand conditions such as malnutrition, hypertension and sickle cell disease in diverse populations. … to study complex childhood diseases, such as early onset hypertension and different forms of malnutrition, teasing …
Staff
Dr. Douglas Stewart is an associate investigator in NHGRI's Center for Precision Health Research.
… tumors, gastrointestinal stromal tumors and pulmonary hypertension. Dr. Stewart's group is using genomic approaches … WC, Kodama M, Meyrick BO, Ross DJ. Is pulmonary arterial hypertension in neurofibromatosis type 1 secondary to a …
Genetic Disorders
Dercum disease is a rare condition that is characterized by multiple, painful fatty tumors that occur chiefly in post-menopausal, obese women of middle age.
… tremors, cyanosis (bluish discoloration of the skin), hypertension (high blood pressure), headaches, and epistaxis …
News Release
Artificial intelligence tools help scientists decode genomic disorders and communicate genomic risks
NHGRI researchers are increasingly using artificial intelligence tools to answer compelling questions in genomics, such as predicting rare genetic disorders and their severity, and to understand how genomic information influences decision-making.
… it would be a boon for more common conditions like cancer, hypertension and diabetes. The results of this study support … it would be a boon for more common conditions like cancer, hypertension and diabetes,” says Dr. Venditti. … Instead of …
News Release
Researchers are asking if the precision medicine approach will reduce or eliminate the role that race plays in prescribing drugs and in health care overall.
… for angiotensin-converting enzyme (ACE) inhibitors for hypertension that recommend using the race of the patient as …
News Release
Researchers build a statistical model using family health history to improve disease risk assessment
Researchers at the National Human Genome Research Institute (NHGRI) have developed a new statistical model that can predict the risk for developing diseases by combining information about family member health and lifestyle factors from family members.
… models that can only be used for complex diseases such as hypertension, high cholesterol and heart disease. In …
Staff
Dr. Charles Rotimi is the scientific director of and NIH Distinguished Investigator in the Division of Intramural Research. He also serves as the director of the Center for Research on Genomics and Global Health (CRGGH).
… His team published the first genome-wide scan for hypertension and blood pressure in African Americans and for … and CARe for Renal Function ( PLoS Genet, 2011). Ongoing hypertension research activities in the branch include …