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Staff
Dr. Lanata is a staff clinician in NHGRI's Genomics of Autoimmune Rheumatic Disease Section.
… I, Jain TS, Nititham J, et al. Transcriptomic analysis of immune cells in a multi-ethnic cohort of systemic lupus …
News Release
NHGRI hosted a CRISPR "Ask Me Anything" with Jennifer Doudna, Ph.D., reaching 10.5 million people worldwide.
… answered nearly a hundred questions about CRISPR, the immune system, and how CRISPR can be used to treat specific … Innovative Genomics Institute. The recent finding of human immune responses to CRISPR-Cas9 proteins in human cells is an …
News Release
Researchers from NHGRI and the Undiagnosed Diseases Program (UDP) have discovered a new neurological condition characterized by issues with motor coordination and speech.
… could provide insights into how the cell’s recycling system contributes to a healthy brain. … Researchers at the …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data​​.
… network models, taking advantage of the dynamics of the system as the cells transition from one physiologic state to … PI(s) Institution Study Title (RePORTER Link) Biological System Alexander Hoffmann, Ph.D. and Douglas Black, Ph.D. … Angeles "Ribonomics" Of Gene Regulation To Predict Innate Immune Responses Post-transcriptional response to pathogens, …
Genetic Disorders
Dercum disease is a rare condition that is characterized by multiple, painful fatty tumors that occur chiefly in post-menopausal, obese women of middle age.
… disorder (a condition that occurs when the body's immune system attacks normal, healthy body tissue). However, no …
News Release
NIH researchers identified a novel role for a gene known as heat shock protein 60, finding it is critical in tissue regeneration and wound healing.
… fins, respectively. Using fluorescently tagged leukocytes (immune cells that flock to the site of injury as part of the … leads the federal government's research on the visual system and eye diseases. NEI supports basic and clinical …
News Release
NHGRI researchers have discovered that Mediterranean populations may be more susceptible to an autoinflammatory disease because of evolutionary pressure to survive the bubonic plague.
… pathogens. This evolutionary battle is between the human immune system and microorganisms trying to invade our bodies. … response of the body. Pyrin is activated when there is an immune response (for example, in the event of an infection). …
The Genomics Landscape
In the August 2023 edition of The Genomics Landscape, NHGRI Director Eric Green introduces incoming NHGRI DEO Director, Jennifer Troyer.
… practices. … Genomics Research Researchers find weaker immune response to viral infections in children with …
Genetic Disorders
Antiphospholipid Syndrome is a disorder characterized by elevated levels of antibodies that are associated with clots in the arteries and veins.
… to its normal size). Thrombocytopenia An association with immune thrombocytopenia (low platelets) has also been … category of autoimmune disorders (conditions caused by an immune response against the body's own tissues). Individuals …
Fact Sheets
Epigenomics is a field in which researchers chart the locations and understand the functions of all the chemical tags that mark the genome.
… can switch on or off genes involved in cell growth or the immune response. These changes can lead to uncontrolled … growth, a hallmark of cancer, or to a failure of the immune system to destroy tumors. In a type of brain tumor called …