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News Release
NHGRI researchers have identified new genes associated with the Erdheim-Chester disease (ECD) and some possible new therapies.
… called histiocytes in different organs. The resulting inflammation damages organs and tissues throughout the body, … Disease leading to their accumulation causing systemic inflammation and organ damage. Credit: … These findings indicate that, despite the presence of inflammation and the absence of metastases (spread of cancer …
News Release
NIH researchers researchers and collaborators have gained some key insights into the biological inner-workings of regrowing a body, the evolution of aging and a unique method to dispose of aging cells, by studying the genomes of a hermit crab (Hydractinia symbiolongicarpus).
… Most studies on senescence are related to chronic inflammation, cancer and age-related diseases. Typically, in … cells stay senescent, and these cells cause chronic inflammation and induce aging in adjacent cells. From animals … cells. “Most studies on senescence are related to chronic inflammation, cancer and age-related diseases,” said Andy …
Staff
Dr. Dan Kastner is an NIH Distinguished Investigator in Metabolic, Cardiovascular and Inflammatory Disease Genomics Branch.
… genomic strategies to understand inherited disorders of inflammation, often stimulated by patients with relatively … of genes underlying inherited human disorders of inflammation, the elucidation of their function, and the … for a motif found in some 20 human proteins involved in inflammation and apoptosis. Soon thereafter, Dr. Kastner's …
News Release
NIH researchers have discovered a rare and sometimes lethal inflammatory disease - otulipenia - that primarily affects young children.
… when the immune system attacks the host's own tissues. Inflammation is the body's natural response to invading … increased production of chemical messengers that lead to inflammation (inflammatory cytokines). The researchers … factor , a chemical messenger involved in systemic inflammation. Inflammation subsided in the children who had …
News Release
The skin microbiota plays an intricate role in the human immune system, directing many immune functions and defending against bacterial pathogens.
… epidermidis produces a secretion that reduces inflammation and speeds wound healing by binding to an … immune system screening, tissue repair, wound healing, inflammation control, production of defensive anti-microbial … programs could be improved if ways are found to reduce inflammation at injection sites by modifying skin …
News Release
NIH has awarded grants of more than $28 million aimed at deciphering the language of how and when genes are turned on and off.
… Rudensky, Ph.D. The body's immune system can cause inflammation, which plays a central role in some diseases. … mechanisms underlying immune system activity during inflammation. They will determine what and when genes are … One cell type promotes the immune system's response and inflammation; the other dampens these functions. Duke …
News Release
Daniel Kastner was named Federal Employee of the Year as part of the 2018 Samuel J. Heyman Service to America Medals program.
… the genomic underpinnings of inherited disorders of inflammation and treating patients at the NIH Clinical Center. Inflammation is the body's response to injury, disease, or …
Graduate Medical Education
An opportunity for a 4-to-8-week elective in the National Human Genome Research Institute (NHGRI) at the NIH Clinical Center in Bethesda, MD.
… Immunotherapy Genomic Medicine Health Services Research Inflammation and Inflammatory Diseases The following programs …
News Release
NHGRI researchers have discovered a new inflammatory disorder called vacuoles, E1 enzyme, X-linked, autoinflammatory and somatic syndrome (VEXAS), which is caused by mutations in the UBA1 gene.
… patients had undiagnosed recurrent fevers and body-wide inflammation. The rest, part of the NIH Undiagnosed Diseases … myeloid cells, which are responsible for systemic inflammation and act as the first line of defense against … treatments for thousands of patients who have various inflammation-related conditions. The study may also pave the …
News Release
Researchers at NHGRI have discovered an immune mechanism in humans that perceives threats and was found only in plants.
… putting the safety pin back in place and quelling the inflammation and fever. The guard mechanism in plants and … important to providing insights into processes like inflammation that, to date, are still not well understood in …