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News Release
Daniel Kastner, M.D., Ph.D., Scientific Director for the Intramural Research Program at the National Human Genome Research Institute (NHGRI) recognized for his pioneering work on the genomics of autoinflammatory diseases.
… NOMID manifests as a disorder that causes persistent inflammation and tissue damage, affecting the nervous system, … , which occur when patients have seemingly unprovoked inflammation, but without the antibodies and T-cells that are …
Research Funding
The Genomics of Gene Regulation project develops methods to construct predictive, accurate gene regulatory network models using genomic data​​.
… Regulatory Programs Of CD4+ T Lymphocyte Populations In Inflammation In vivo inflammation model, mouse T helper cells Jeremy Luban, M.D. …
News Release
Researchers at the National Institutes of Health and their colleagues have identified genomic variants that cause a rare and severe inflammatory skin disorder, known as disabling pansclerotic morphea, and have found a potential treatment.
… version of a protein called STAT4, which regulates inflammation and wound healing. The work also identified a … these four patients, creating a positive feedback loop of inflammation and impaired wound-healing that worsens over …
News Release
NIH researchers identified a novel role for a gene known as heat shock protein 60, finding it is critical in tissue regeneration and wound healing.
… protein was somehow acting as an attractant that promoted inflammation, a necessary component of wound healing. "When … tissue regeneration and wound healing by regulating inflammation and cell proliferation . npj Regenerative …
Clinical Research
A study with the goal of finding the genetic cause of familial Mediterranean fever (FMF) and several novel and undiagnosed causes of autoinflammatory disease.
… by seemingly unprovoked episodes of systemic or localized inflammation, without evidence of infection and without the … How to Bake Cookies  Demystifying Medicine 2017: Inflammation: One Gene at a Time … Lab Team Brynja …
News Release
NIH investigators have discovered that genomic switches of a blood cell are key to regulating the human immune system.
… fellow in Dr. O'Shea's lab in the Molecular Immunology and Inflammation Branch. The study was performed in collaboration … immune system mistakenly attacks its own cells, causing inflammation. Different tissues are affected in different …
Fact Sheets
Genome-wide association studies involve scanning markers across the genomes of many people to find genetic variations associated with a particular disease​.
… factor H, which produces a protein involved in regulating inflammation. Few previously thought that inflammation might contribute so significantly to this type …
15 Ways Genomics Influences Our World
Genomics is ending diagnostic odysseys for patients with rare diseases.
… a mutation in the gene NLRP3,  which causes abnormal inflammation throughout the body. After only one treatment with a medicine to dampen this inflammation, Zarko's symptoms improved. Just like Sonia and …
Genetic Disorders
Antiphospholipid Syndrome is a disorder characterized by elevated levels of antibodies that are associated with clots in the arteries and veins.
… with recurrent pregnancy loss, thrombophlebitis (inflammation of a vein related to a blood clot) and lupus … neuropathy, transverse myelitis (a disorder caused by inflammation across both sides of one level, or segment, of …
Staff
Dr. Manfred Boehm is a an adjunct investigator for the Office of the Clinical Director at NHGRI.
… production in vascular smooth muscle cells modulates inflammation following arterial injury in mice. J. Clin. …