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Staff
Dr. Sharon Milgram is an adjunct investigator in the Genetics and Molecular Biology Branch at the National Human Genome Research Institute.
… biochemical assays to physiological assays in knock-out mice. … Altschuler Y, Hodson C, Milgram SL. The apical … chorioallantoic fusion, and embryonic axis elongation in mice with targeted disruption of Yap65. Mol Cell Biol , …
News Release
NHGRI researchers will present four platform talks and 55 posters to highlight the institute's diverse portfolio at the 65th annual meeting of ASHG.
… alleles in the vitamin B12 receptor, CD320, in humans and mice. (Molecular Basis of Mendelian Disorders) 2819W. … Disorders) *2271T. Oleg Schelochkov: A Zebrafish Knockout of Argininosuccinate Lyase Separates Ureagenic and … carriers. (Metabolic Disorders) *2313T. Peter J. McGuire: Mice lacking Cox10 in T-lymphocytes recapitulate the immune …
News Release
Researchers have identified genomic mutations for Carey-Fineman-Ziter syndrome, a congenital myopathy with facial weakness, a cleft palate and scoliosis.
… each family, only the gene MYMK was common to all three. A knockout mouse model (genomically altered mice that are bred to lack a specific gene) displayed a … muscle development, leading to early death of the newborn mice, making this gene a promising candidate for further …
News Release
Scientists drafted the blueprint for how to build a common goldfish. Now they'll use it to find out what gives ornamental goldfish their nuanced features, gaining insight into human health.
… 60 million years ago, a similar distance as between mice and humans. The common carp's DNA was already sequenced. … or remove a gene from an animal. Researchers use this "knockout" technique to study how genes affect animals. Yet … new functions for genes. This is a natural complement to ‘knockout' laboratory studies.  Co-first author Dr. Yoshihiro …
News Release
Researchers show critical association between diabetes and previously unlinked ZRANB3 gene.
… make the ZRANB3 gene inoperative in zebrafish (called a ‘knockout’). They also used biological tools to reduce the … such β-cell death, the researchers took β-cell cells from mice and performed a similar knockdown of the ZRANB3 gene as …
Staff
Dr. Charles Venditti is a chief and senior investigator of NHGRI's Metabolic Medicine Branch.
… acid metabolism in model organisms, including roundworms, mice and zebrafish. Using a translational research approach, … all the studies are striking: while the untreated Mut-/- mice uniformly perish in early life, the Mut-/- mice that receive AAV gene therapy with any of the section's …
Staff
Dr. Raman Sood is an associate investigator in the Translational and Functional Genomics Branch and director of the Zebrafish Core at the National Human Genome Research Institute.
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… Dr. Sood has generated and characterized gene knockout mutants for several important hematopoietic genes. … CRISPR/Cas9 to generate single or multiple gene knockout mutants in zebrafish. To date, the core has … SM. Highly-efficient Cpf1-mediated gene targeting in mice following high concentration pronuclear injection . G3. …
File
… or undiagnosed diseases–Genes depleted for LoFvariants–Knockout genes that generate a phenotype in mice–Gene families targetable by drugs•Criteria for …
The Genomics Landscape
In the February 2018 edition of The Genomics Landscape, NHGRI Director Eric Green highlights the new director of NHGRI's Division of Genome Sciences.
… Fund Programs - the Human Microbiome Project (HMP), the Knockout Mouse Phenotyping (KOMP2) Program; the Human … Goes Viral NIH Scientists Find Microbes on the Skin of Mice Promote Tissue Healing, Immunity Researchers Study …
Staff
Cynthia Tifft, M.D., Ph.D. is the deputy clinical director for the National Human Genome Research Institute.
… could double the lifespan of Sandhoff disease mice, not by decreasing the storage of GM2 ganglioside, but …