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News Release
Researchers are trying to understand a process whose rules are constantly being written and rewritten by cancer's rogue cells: who will more likely relapse.
… In recent research published online in July in the journal Leukemia, Paul Liu, M.D., Ph.D., asenior investigator and … with a specific kind of relapse-prone acute myeloid leukemia (AML). Though AML is generally thought to be a … American Cancer Society. "We're trying to understand why leukemia patients relapse, and if there are any DNA-level …
Staff
Dr. Paul Liu is a senior investigator in NHGRI's Translational and Functional Genomics Branch.
… Liu's research over the years has been the mechanism of leukemia development at the molecular level, using genetic … a common chromosome abnormality in human acute myeloid leukemia. Using animal models, Dr. Liu has illustrated the importance of CBFB-MYH11 for leukemia development, and how this fusion gene works. His …
15 Ways Genomics Influences Our World
Genomics is transforming how we study, diagnose and treat cancer.
… diagnosed with a blood cancer called acute lymphoblastic leukemia (or ALL) in 2003, when he was in his fourth year of … This led him to specialize in treating patients with leukemia, and studying the disease in the laboratory. While … better results by Monday. After a number of weeks, the leukemia cells were no longer detectable in his blood, …
News Release
Scientists are exploring the genomic and clinical profiles of people with RUNX1 familial platelet disorder.
… cancers, such as myelodysplastic syndrome, acute myeloid leukemia and acute lymphoblastic leukemia. Many people with this disorder may also have skin … there features that might predict if someone would develop leukemia?” … In the first study, published in the journal …
Profile
After major advances in hematology, David Bodine retires with an eye towards mentorship and a garden
David Bodine, founder of the Hematopoiesis Section and chief of the Genetics and Molecular Biology Branch, advanced the fields of gene therapy and hematology in his 38 years at the NIH. Now, he plans to continue his contributions to science as an emeritus and through training the next generation of scientists.
… and ask, “Why does that one stem cell go nuts and become leukemia? Is it because of where it is, or is it because of … If you could then change the microenvironment and cure leukemia that way, it'd be a lot better than chemotherapy. … …
Educational Resources
Gene therapy is an experimental technique for treating disease by altering the patient's genetic material.
… and sickle cell disease) and acquired disorders (e.g., leukemia) have been treated with gene therapy. … Educational …
Clinical Research
A study where both genotypic (individual genetics) and phenotypic (individual disease characteristics) patient data would be analyzed using advanced data-analytics programs to derive meaningful associations for the development of prevention, management and treatment strategies.
… only receive deidentified information. If I develop leukemia and require a bone marrow transplant can I have the … understand what changes occur in patients who progress to leukemia as compared to those who don’t, since it is believed that leukemia is developed from the blood precursor cells in the …
Research Funding
Effort to accelerate understanding of the molecular basis of cancer using genome analysis technologies, including large-scale genome sequencing.
… researchers identify potential drug targets, markers for leukemia risk (2013) Study reveals genomic similarities … Researchers discover key mutation in acute myeloid leukemia (2010) The Cancer Genome Atlas Identifies …
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… (Purinethol) to patients with acute lymphoblastic leukemia. Some people have a genetic variant that interferes … of the treatment options for childhood acute lymphoblastic leukemia [cancer.gov] is stem cell transplantation therapy. …
News Release
The zebrafish is a powerhouse tool that helps researchers better understand the genes that are implicated in disease.
… changes that lead to certain blood cancers, such as leukemia. Although Dr. Liu acknowledged that the zebrafish is not a proven model for leukemia, its transparent embryos develop in the water away …