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Educational Resources
A promoter is a sequence of DNA needed to turn a gene on or off.
… Gene, Gene Expression, Gene Regulation, Messenger RNA (mRNA), Transcription … A promoter, as related to genomics, is … resulting transcription produces an RNA molecule (such as mRNA). … A promoter is a sequence of DNA needed to turn a …
Educational Resources
Transfer RNA (tRNA) is a small RNA molecule that participates in protein synthesis.
… Anticodon, Base Pair, Codon, Genetic Code, Messenger RNA (mRNA), Protein, Ribosome, Translation, Amino Acids … Transfer … serves as a link (or adaptor) between the messenger RNA (mRNA) molecule and the growing chain of amino acids that make … specific tRNA pairs with its complementary sequence on the mRNA molecule, ensuring that the appropriate amino acid is …
Educational Resources
The nucleolus is a region found within the cell nucleus that is concerned with producing and assembling the cell's ribosomes.
… and assembling the cell's ribosomes. … Messenger RNA (mRNA), Ribonucleic Acid (RNA), Translation, Cell, Cytoplasm, …
Educational Resources
Ribonucleic acid (RNA) is a molecule similar to DNA. Unlike DNA, RNA is single-stranded.
… Uracil, Adenine, Cytosine, Guanine, Messenger RNA (mRNA), Ribosome … Ribonucleic acid (abbreviated RNA) is a … (G). Different types of RNA exist in cells: messenger RNA (mRNA), ribosomal RNA (rRNA) and transfer RNA (tRNA). In …
Educational Resources
Transcription is the process of making an RNA copy of a gene sequence.
… Acid (DNA), Gene, Gene Expression, Messenger RNA (mRNA), Nuclear Membrane, Nucleus, Ribosome, Translation, … of a gene’s DNA sequence. This copy, called messenger RNA (mRNA), carries the gene’s protein information encoded in DNA. In humans and other complex organisms, mRNA moves from the cell nucleus to the cell cytoplasm …
Staff
Dr. Randy Chandler is an associate investigator in the Organic Acid Research Section of the Metabolic Medicine Branch in NHGRI.
… models have helped enable two clinical trials: one uses mRNA therapy and the other, AAV-mediated nuclease-free genome … approaches, such as AAV gene delivery, genome editing, and mRNA therapy, to cure rare genetic disorders. The primary … for MMA and PA. In addition, his research has shown that mRNA therapy and gene editing approaches could also be …
Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
… kinds of RNA. The major type, called messenger RNA (mRNA), plays a vital role in making proteins. In this process: mRNA is transcribed from genes; then the mRNA transcripts are delivered to ribosomes , the molecular …
Research Funding
A list of current and previous Centers of Excellence in Genomic Science (CEGS) grant awards.
… by developing a massively parallel single-cell mRNA profiling method. Center-developed technologies will be … Chicago Chemical modifications on mammalian messenger RNA (mRNA) have recently been shown to play critical and diverse regulatory roles in mRNA metabolism and translation. For example, the most …
For Teachers
Tools and resources for teaching the concepts of transcription and translation, two key steps in gene expression
… of a gene sequence. This copy, called a messenger RNA (mRNA) molecule, leaves the cell nucleus and enters the … process of translating the sequence of a messenger RNA (mRNA) molecule to a sequence of amino acids during protein … the cell cytoplasm, the ribosome reads the sequence of the mRNA in groups of three bases to assemble the protein. Here …
Fact Sheets
Deoxyribonucleic acid (DNA) is a molecule that contains the biological instructions that make each species unique.
… molecule called messenger ribonucleic acid, or mRNA. Next, the information contained in the mRNA molecule is translated into the "language" of amino … a template. This template strand is then transcribed into mRNA, which is a molecule that conveys vital instructions to …