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For Teachers
Tools and resources for teaching the concepts of transcription and translation, two key steps in gene expression
… your students. Many times the unfamiliar vocabulary is the major stumbling block to student comprehension. This app/site … could be adapted for upper-level courses by including more complex problems and aspects of gene expression, such as the …
The Genomics Landscape
In the January 2020 edition of The Genomics Landscape, NHGRI Director Eric Green highlights the newly developed polygenic risk scores webpage, which provides graphical and textual information about polygenic risk scores, describes polygenic traits, introduces how polygenic risk scores can be calculated, and explains how such scores can be interpreted.
… need for international research collaborations to tackle major challenges in genomic and precision medicine. It will … interdisciplinary program that will include both major research projects as well as core facilities that will facilitate use of the growing datasets emanating from major cohort studies (such as the UK Biobank and the All of …
Fact Sheets
Deoxyribonucleic acid (DNA) is a molecule that contains the biological instructions that make each species unique.
… Besides the DNA located in the nucleus, humans and other complex organisms also have a small amount of DNA in cell … that can be used to produce proteins, which are the complex molecules that do most of the work in our bodies. … the amino acids to produce a specific protein. This is a major task because there are 20 types of amino acids, which …
Health
A polygenic risk score is one way by which people can learn what their risk of developing a disease is, based on the total number of genomics variants related to the disease.
… Each larger “V” represents a CFTR gene mutation. … Complex diseases occur as a result of many genomic variants, … not implicated in disease. Coronary artery disease is a complex disease. Researchers have found about 60 genomic … … Researchers identify genomic variants associated with complex diseases by comparing the genomes of individuals with …
File
… genes of unknown function, 3 SNPs in HLA -A – class 1 MHC 71% prevalence in asymptomatics compared to 29 % in …
Educational Resources
Proteins are an important class of molecules found in all living cells.
… Amplification, Amino Acids, Gene … Proteins are large, complex molecules that play many important roles in the body. …
News Release
H3Africa Consortium Array Will Bring Leading-Edge Genomics Tool to Address African Genomic Diversity
Illumina will be developing a GWAS array based on data from the Human Heredity and Health in Africa Initiative.
… Amy Bentley … In a major advance for those engaged in genomic research in …
Fact Sheets
Chromosomes are thread-like structures located inside the nucleus of animal and plant cells.
… found in the nucleus, the cells of humans and other complex organisms carry a much smaller type of chromosome … help to keep chromosomes properly aligned during the complex process of cell division. As chromosomes are copied … plant has 12 and a dog, 39. … In humans and most other complex organisms, one copy of each chromosome is inherited …
The Genomics Landscape
In the August 4, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., talks about the establishment of the Global Biodata Coalition (GBC), which aims to move towards more internationally coordinated, sustainable, and streamlined mechanisms that support the biodata ecosystem.
… of their funding support. This situation is made even more complex by the demographics associated with funding data … how to improve this problematic situation. One of the major outputs of that meeting was a call for the creation of … Genome Program architects and the researchers involved in major genomics initiatives that have followed, NHGRI has an …
Educational Resources
Gene environment interaction is an influence on the expression of a trait that results from the interplay between genes and the environment.
… are influenced by how one or more genes interact in complex ways with environmental factors, such as chemicals in …