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Dr. Colin Fletcher is the program director in the Knockout Mouse Project (KOMP) in NHGRI's Extramural Research Program.
… is principally responsible for supervising The Knockout Mouse Project (KOMP). The goal of the KOMP program, expected … of 8,500 knockouts of mouse genes, in the form of embryonic stem (ES) cells. He is now working to implement The Knockout …
Educational Resources
A stem cell is a cell with the potential to form many of the different cell types found in the body.
… Stem Cell … A stem cell is a cell with the potential to form … of the different cell types found in the body. When stem cells divide, they can form more stem cells or other cells that perform specialized functions. Embryonic stem cells have the potential to form a complete …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… A knockout mouse is a laboratory mouse in which researchers have … into adult mice. The lack of adult mice limits studies to embryonic development and often makes it more difficult to … disease.  … Researchers begin by harvesting embryonic stem (ES) cells from early-stage mouse embryos four days …
News Release
A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
… cell to its earliest stage of development (a pluripotent stem cell) and change it into different types of cells in the body. … Called induced pluripotent stem cells (iPSCs), this technique opens the doors to medical …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… tell the genome what to do - among three types of cells: mouse embryonic stem (ES) cells, embryonic fibroblasts and hematopoietic …
News Release
Researchers have found powerful clues to why certain processes and systems in the mouse are so different from those in people.
… powerful clues to why certain processes and systems in the mouse - such as the immune system, metabolism and stress … so different from those in people. Building on years of mouse and gene regulation studies, they have developed a … by mouse and human and were active in different types of cells. "We looked inside the shared regulatory sequences and …
News Release
In a study published in the journal Science, collaborators at NHGRI, the National University of Ireland, Galway, and the Whitney Laboratory for Marine Bioscience at the University of Florida, Augustine, reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ cells in a cycle that can repeat endlessly.
… called Hydractinia, does so because it produces germ cells, which are precursors to eggs and sperm, nonstop … reported that activation of the gene Tfap2 in adult stem cells in Hydractinia can turn those cells into germ … similar to gonads in species like humans. During human embryonic development, a small pool of germ cells that will …
Educational Resources
A mouse model is a laboratory mouse used to study some aspect of human physiology or disease.
… Mouse Model … A mouse model is a laboratory mouse used to study some aspect of human physiology or disease. … Mouse Model, Knockout Mouse, Genetic Engineering, Laboratory …
Research Funding
The Knockout Mouse Phenotyping Project (KOMP2) collaborates with the International Mouse Phenotyping Consortium (IMPC) to knockout and characterize all protein-coding genes in the mouse genome.
… K The Jackson Laboratory The Jackson Laboratory Knockout Mouse Production and Phenotyping Project (JAX KOMP2) OD023222 … centers produced 8,500 of the 17,500 total knockouts in embryonic stem cells. Launched in 2011 as a Common Fund and Trans-NIH …
Educational Resources
A somatic cell is any cell of the body except sperm and egg cells.
… Somatic Cells … A somatic cell is any cell of the body except sperm and egg cells. … Cell, Chromosome, Diploid, Mutation, Germ Line … Somatic cells are the cells in the body other than sperm and egg …