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Educational Resources
Sickle cell disease is a hereditary disease seen most often among people of African ancestry.
… recessive trait. The mutation causes the red blood cells to take on an unusual sickle shape. Individuals …
Staff
Lisa Garrett is an associate investigator and director of the NHGRI Transgenic Mouse Core.
… is a staff scientist and director of the NHGRI Transgenic Mouse Core at the NIH. In 1984, she received her M.S. at … In 1994, Ms. Garrett began as a supervisor in the NHGRI Embryonic Stem Cell and Transgenic Mouse Core and became director in …
Educational Resources
Apoptosis is the process of programmed cell death.
… It is used during early development to eliminate unwanted cells; for example, those between the fingers of a developing … hand. In adults, apoptosis is used to rid the body of cells that have been damaged beyond repair. Apoptosis also …
Fact Sheets
A transcriptome is a collection of all the gene readouts present in a cell.
… contains the instructions needed to build and maintain cells. These instructions are spelled out in the form of … the world-the Mammalian Gene Collection initiative and the Mouse Transcriptome Project. The Mammalian Gene Collection … initiative built a free, public library of human, mouse, and rat mRNA sequences. The project was led by NHGRI …
Staff
Dr. Paul Liu is a senior investigator in NHGRI's Translational and Functional Genomics Branch.
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… gene CBFB - MYH11, Dr. Liu's group generated a knock-in mouse model, which demonstrated that CBFB - MYH11 blocks … mouse models. The zebrafish is a useful model for studying embryonic development and is easily amenable to large-scale … made novel findings regarding its role in hematopoietic stem cell production (Bresciani, Blood in press). Overall the …
Research Funding
The Encyclopedia of DNA Elements (ENCODE) aims to identify all functional elements in the human and mouse genomes.
… Mapping of Long-Range Chromatin Interactions in Human and Mouse Genomes UM1 HG009409 Michael Snyder Stanford University … University of California, Irvine High Precision Human and Mouse Transcriptomes UM1 HG009443 Functional Characterization … … As the ENCODE Project has increased its study of primary cells and tissues, it has begun working on human biological …
Educational Resources
The nucleolus is a region found within the cell nucleus that is concerned with producing and assembling the cell's ribosomes.
Event
The National Human Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International Mouse Phenotyping Consortium (IMPC)'s annual meeting at the Rockville Hilton in Rockville, Maryland, on November 19, 2019.
… Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International Mouse Phenotyping Consortium (IMPC)'s annual meeting at the … Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International Mouse …
Educational Resources
Mitochondria are membrane-bound cell organelles (mitochondrion, singular) that generate most of the chemical energy needed to power the cell's biochemical reactions.