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News Release
NIH is launching a program, Molecular Phenotypes of Null Alleles in Cells (MorPhiC), to better understand the function of every human gene and generate a catalog of the molecular and cellular consequences of inactivating each gene.
… Alleles in Cells program will first look at protein-coding genes … The National Institutes of Health is launching a … Phase 1 of the program will focus on 1,000 protein-coding genes and serve as a pilot phase and has three goals: … at the level of tissues and organs as part of the Knockout Mouse Program. Another effort is applying new technologies, …
Research Funding
The Encyclopedia of DNA Elements (ENCODE) aims to identify all functional elements in the human and mouse genomes.
… Mapping of Long-Range Chromatin Interactions in Human and Mouse Genomes UM1 HG009409 Michael Snyder Stanford University … University of California, Irvine High Precision Human and Mouse Transcriptomes UM1 HG009443 Functional Characterization … Exploring Candidate Regulatory Elements, Linked Genes and Genetic Variation with SCREEN, October 2017, ASHG …
News Release
NIH researchers have identified a gene that makes yeast resistant to a lethal toxin.
… of resistant versus sensitive yeast to identify which genes confer resistance to the toxin.  Through this …
Event
The National Human Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International Mouse Phenotyping Consortium (IMPC)'s annual meeting at the Rockville Hilton in Rockville, Maryland, on November 19, 2019.
… Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International Mouse Phenotyping Consortium (IMPC)'s annual meeting at the … Genome Research Institute (NHGRI) hosted the Knockout Mouse Phenotyping Program (KOMP2) and International Mouse …
Fact Sheet
Today, gene therapy for sickle cell disease is considered experimental and only available to you if you participate in a clinical trial.
News Release
Researchers identified 13 gene regions that influence cholesterol levels, some of which affected people differently if they are smokers or former smokers.
… in heart-clogging cholesterol but the role that a smoker's genes play in their cholesterol levels has been a mystery - … data on nearly 400,000 individuals to search for how genes interact with smoking in the context of lipid levels. …
News Release
Researchers at the NHGRI's Undiagnosed Disease Program have developed a new toolset for finding potential disease-causing gene variants in undiagnosed patients.
… hours per exome to analyze an individual's protein-coding genes. … The UDP is part of the Undiagnosed Diseases Network … gene variants. Researchers found, on average, 6.6 faulty genes in people with undiagnosed diseases compared to 5.8 faulty genes in their healthy brothers and sisters. Researchers then …
The Genomics Landscape
In the August 6, 2020 edition of The Genomics Landscape, Dr. Eric Green talks about NHGRI's completion of the third phase of the ENCODE Project and how it reveals the most extensive catalog to date of candidate functional elements that may regulate the genes in the human and mouse genomes.
… aims to identify all functional elements in the human and mouse genomes. The project recently reported the findings … of candidate functional elements that may regulate the genes in the human and mouse genomes. Much of the work focused on DNA regions called …
News Release
NIH researchers identified a novel role for a gene known as heat shock protein 60, finding it is critical in tissue regeneration and wound healing.
… gel dramatically accelerates wound closure in a diabetic mouse model. … The study also describes the mechanism by …
News Release
It’s teatime and doctors, researchers and patients are at the table. They celebrate a decade of work and launch the first in-human gene therapy trial for children with a rare and devastating disease, GM1 gangliosidosis.
… her neurons. At the time, no one knew. Jojo inherited the genes for GM1 gangliosidosis from her mother and father. … try to take over their micro-world by delivering their genes to the host and replicating themselves. Viral … be harnessed to do the same work, except deliver helpful genes? Sena-Esteves attempted exactly that by removing the …