Search Results

41 - 50 of 1048
News Release
NIH researchers have developed and released an innovative software tool, called Verso, to assemble truly complete (i.e., gapless) genome sequences from a variety of species. The software makes the process of assembling complete genome sequences more affordable and accessible.
… complete genome sequence.” The T2T consortium used new DNA sequencing technologies and analytical methods to generate … like putting together a jigsaw puzzle, and different DNA sequencing technologies generate different types of genomic … researchers tested Verkko with human and non-human genome sequencing data. The software quickly and precisely assembled …
Educational Resources
An anticodon is a trinucleotide sequence complementary to that of a corresponding codon in a messenger RNA (mRNA) sequence.
Educational Resources
A contig is a series of overlapping DNA sequences used to make a map that reconstructs the original DNA sequence of a chromosome or a region of a chromosome.
The Genomics Landscape
In the October 6, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., celebrates the 25th anniversary of the NIH Intramural Sequencing Center (NISC). a well-respected and highly used large-scale DNA sequencing center that exemplifies the evolution of the field of genomics and the ever-increasing abilities to produce prodigious amounts of genomic data.
… sequence to public databases weekly, as large-scale DNA sequencing had advanced substantially. At that time, it … and medicine. From the beginning, NISC emphasized the generation of the highest data quality possible and the … This included the importation of the powerful new “next-generation” DNA sequencing technologies as they matured …
Profile
Jim Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics.
… Mullikin pioneered DNA sequencing technologies during the Human Genome Project and … the whole progress, from the very early days of Sanger sequencing all the way to a complete telomere-to-telomere … NISC has evolved in tandem with rapidly advancing DNA sequencing technologies. When I was appointed acting director …
Fact Sheets
Comparative genomics is a field of biological research in which researchers compare the complete genome sequences of different species.
… biology of living things have changed over time. As DNA sequencing technology becomes more powerful and less … list continues to grow almost daily. In addition to the sequencing of the human genome, which was completed in 2003, … critical data for understanding genetic variation. DNA sequencing centers supported by NHGRI also have sequenced …
Staff
Dr. Gerard Bouffard directs the Bioinformatics Group at the NIH Intramural Sequencing Center (NISC).
… where he combined his interests in early genome sequencing of the Escherichia coli genome with the nascent … expedited gene discovery on this chromosome, and directed sequencing efforts in the early days of the Human Genome … facility for the rapid, accurate and cost-effective generation of DNA sequence data. … Bouffard, G., J. Ostell, …
Media Advisory
The National Institutes of Health (NIH) will host researchers from the Telomere-to-Telomere (T2T) consortium, who have now sequenced the remaining 8% of DNA that was unable to be sequenced by the Human Genome Project and has eluded researchers for nearly two decades.
… What: Virtual press conference to announce T2T consortium sequencing a complete human genome Moderator: Eric Green, …
Educational Resources
Cloning is the process of making identical copies of an organism, cell, or DNA sequence.
The Genomics Landscape
In the April 7, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., highlights the Telomere-to-Telomere (T2T) consortium's publishing of a collection of papers that reported the first truly complete sequence of the human genome.
…     …   In 2003, the Human Genome Project ended with the generation of an essentially complete sequence of the human … approach of using the best-available technologies for sequencing DNA and pushing them to their absolute limits. In … filling in the remaining bits because the technologies for sequencing DNA at that time were clearly not up to the task. …