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The Genomics Landscape
In the March 3, 2022 edition of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., highlights the new fact sheets produced by the institute's Communications and Public Liaison Branch.
… dialogues about current themes and issues in genomics. The polygenic risk score fact sheet describes how information about genomic … person’s risk for certain human diseases and how such risk scores may be used in medicine. During the COVID-19 pandemic, …
News Release
NIH will renew three awards totaling $73.2 million over five years to continue building the Clinical Genome (ClinGen) resource, an effort to collect and archive information about clinically relevant genes and genomic variants for use in precision medicine.
… information and guidelines for studies that evaluate polygenic risk scores. Researchers have used these ClinGen resources to …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in February 2022.
… Using HCR-FlowFISH Nasser - Genome-Wide Enhancer Maps Link Risk Variants to Disease Genes Zhang - A Single-Cell Atlas of … Network eMERGE Network Website eMERGE Resources Kullo - Polygenic Risk Scores for Diverse Ancestries: Making Genomic Medicine …
Funded Research
The Advancing Genomic Medicine Research (AGMR) program stimulates innovation and advance understanding of when, where and how best to implement the use of genomic information and technologies in clinical care.
… Ann Orlando Duke University Deploying a Genomic Medicine Risk Assessment Model for Diverse Primary Care Populations … University Medical Center Rational Integration of Polygenic Risk Scores (RIPS) Kathryn A. Phillips University of California, …
News Release
Supporting early career investigators at the cutting edge of genomics.
… NIH grant programs with a similar purpose include the High Risk, High Reward Research program funded by the NIH Common … School, Boston, aims to develop and validate clinical polygenic risk scores for six common diseases: coronary artery disease, …
Research Funding
ClinGen will advance genomics in clinical care and improve our understanding of phenotypic and functional effects of genetic variants and their clinical value.
… information in clinical genomics and complex (eg. polygenic) disease score reporting. Finally, they are active … genes that, when significantly altered, confer a high risk of serious disease that could be prevented or mitigated … Wojcik Define common language for describing complex risk scores and methodology, create guidelines for assessing the …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in September 2021.
… (R01) 19 Genome-Wide Association Studies (GWAS) Catalog 20 Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium …
Research Funding
The Division of Genomic Medicine promotes the NHGRI's efforts to advance the application of genomics to medical science and clinical care.
… 9-10, 2021, Virtual  Genomic Medicine XII: Genomics and Risk Prediction May 6-7, 2019, Silver Spring, Md.  Genomic … Webinar for RFA-HG-20-001 and RFA-HG-20-002, Polygenic Risk Score (PRS) Methods and Analysis for … Population Genetics and Computational Methods Related to Polygenic Prediction of Health and Disease in Diverse …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in September 2023.
… Resource (ClinGen) ClinGen Website ClinVar Website 23 Polygenic Risk MEthods in Diverse Populations Consortium (PRIMED) … – "Principles and Methods for Transferring Polygenic Risk Scores Across Global Populations" Ding et al. – "Polygenic …
National Advisory Council for Human Genome Research
The Director's Report-Related Documents contain links to materials supplemental to Dr. Eric Green's Director's Report presentation to the National Advisory Council for Human Genome Research in May 2021.
… Genome Resource (ClinGen) ClinGen Program Website Polygenic Risk Scores (PRS) Reporting Framework Polygenic Score (PGS) …