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News Release
Researchers are trying to understand a process whose rules are constantly being written and rewritten by cancer's rogue cells: who will more likely relapse.
… being written and rewritten by the cancer's rogue cells. Untangling the genetic influences on these rules will … that, when mutated, seemed to cause a relapse and drive blood cells that are still in production in the bone marrow … relapse, GATA2, is a sort of "master" switch that controls blood cell production in the bone marrow. In other research, …
News Release
A team from the NIH has surmounted a major obstacle to testing potential drug therapies for a rare, genetic condition called Gaucher disease.
… Medicine that they have succeeded in coaxing cultured cells to exhibit the signature traits of the disease. Using … enlargement of the liver and spleen, a low number of red blood cells, easy bruising caused by a decreased blood …
News Release
NIH awards more than $64 million to for a database of human cellular responses called the Library of Integrated Network-based Cellular Signatures or LINCS.
… Institute (NHGRI) and the National Heart, Lung, and Blood Institute (NHLBI), both part of NIH, administer the … and genetic factors - that are potentially disruptive to cells. LINCS researchers then will measure the cells' tiniest … the causes, prevention, diagnosis, and treatment of heart, blood vessel, lung, and blood diseases; and sleep disorders. …
Talking Glossary
Mosaicism refers to the presence of cells in a person that have a different genome from the body’s other cells.
… Mosaicism … Mosaicism refers to the presence of cells in a person that have a different genome from the body’s other cells. … Mosaicism refers to the presence of cells in a person that have a different genome from the …
News Release
Learn what happens when two genetic neighborhoods merge in brain tumor cells after a gene controlled by a gene-control switch turned on a cancer-growth gene.
… when two genetic neighborhoods merge in brain tumor cells. Researchers found that one gene came under the control … IDH gene was mutated, particular portions of the cancer cells' DNA became studded with chemical tags called methyl … of these genetic neighborhoods, a gene called PDGFRA makes cells grow, or increase in number, but is rarely turned on. …
Talking Glossary
Chromosomes are threadlike structures made of protein and a single molecule of DNA that serve to carry the genomic information from cell to cell.
… (including humans), chromosomes reside in the nucleus of cells. Humans have 22 pairs of numbered chromosomes …
The Genomics Landscape
In the July 2021 issue of The Genomics Landscape, NHGRI Director, Eric Green, M.D., Ph.D., reflects on the legacy the LINCS program leaves as it has completed its goal of creating a large-scale, systematically generated molecular and cellular dataset.
… settings, making genomic testing as routine as complete blood counts (CBCs). Speakers: Jennifer Posey, M.D., Ph.D., … and cellular dataset to help scientists understand how cells respond to specific biological and environmental … LINCS program generated dataset to help understand how cells functio … NHGRI and NCI award $33 million to improve …
News Release
NHGRI researchers asked patients, parents and physicians in the sickle cell disease community (SCD) what they wanted and needed to know about genome editing to make informed decisions about participating in genome-editing clinical trials.
Talking Glossary
A gamete is a reproductive cell of an animal or plant.
… or plant. In animals, female gametes are called ova or egg cells, and male gametes are called sperm. Ova and sperm are haploid cells, with each cell carrying only one copy of each …
Educational Resources
Bacteria are small single-celled organisms.
… and in fact is estimated to contain more bacterial cells than human cells. Most bacteria in the body are harmless, and some are …