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Talking Glossary
Next-generation DNA sequencing (abbreviated NGS) refers to the use of technologies for sequencing DNA that became available shortly after the completion of the Human Genome Project (which relied on the first-generation method of Sanger sequencing).
News Release
Baylor College of Medicine. Houston and the Medical College of Wisconsin, Milwaukee will be providing DNA sequencing for the Undiagnosed Diseases Network.
News Release
Micro-sized technologies are among the approaches researchers will use to develop high quality, low cost DNA sequencing technology.
Infographic
An infographic that explains why it was so difficult to fully complete the human genome sequence.
… of random pieces of DNA and then use those smaller sequences to put the whole genome sequence back together like …
News Release
The Telomere-to-Telomere (T2T) Consortium has generated the first truly complete sequence of a human Y chromosome - the final human chromosome to be fully sequenced.
… human genome sequence 20 years ago, gaps were left in the sequences of all 24 chromosomes. However, unlike the small … is made of alternating blocks of two specific repeating sequences known as satellite DNA. It makes a beautiful, … 30 million letters of the Y chromosome are repetitive sequences. It’s as if the same few sentences were repeated …
Research Funding
GS-IT provides sequence analysis tools and software to scientists who rely on genomics in their research.
News Release
NHGRI researchers have produced the first end-to-end DNA sequence of a human chromosome. The results show that generating a precise, base-by-base sequence of a human chromosome is now possible, and will enable researchers to produce a complete sequence of the human genome.
… NHGRI director. “The ability to generate truly complete sequences of chromosomes and genomes is a technical feat that … However, there are hundreds of gaps or missing DNA sequences that are unknown. These gaps most often contain … into smaller pieces, then analyze each piece to yield sequences of a few hundred bases at a time. Those shorter …
The Genomics Landscape
In the January 2018 edition of The Genomics Landscape, NHGRI Director Eric Green features the NIH Intramural Sequencing Center.
News Release
Scientists have published the first complete, gapless sequence of a human genome, two decades after the Human Genome Project produced the first draft human genome sequence.
… The researchers noted that most of the newly added DNA sequences were near the repetitive telomeres (long, trailing … methods alone still leaves some gaps in assembled genome sequences. The massive drop in DNA sequencing costs comes …
The Genomics Landscape
In the July 2020 edition of The Genomics Landscape, NHGRI Director Eric Green recalls the White House event announcing the draft human genome sequence.