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News Release
NHGRI researchers asked patients, parents and physicians in the sickle cell disease community (SCD) what they wanted and needed to know about genome editing to make informed decisions about participating in genome-editing clinical trials.
… of Health, asked patients, parents and physicians in the sickle cell disease community what they wanted and needed to know … treatments, which appear to provide a potential for sickle cell, are among the most widely publicized medical …
Fact Sheet
Understanding gene therapy for sickle cell disease
… Sickle cell disease is the most common inherited blood disorder in … there are only a handful of options to manage or treat sickle cell disease.  Now, researchers are developing new and …
Educational Resources
A cell is the basic building block of living things.
… Cell … A cell is the basic building block of living things. … Eukaryotes, Prokaryotes, Basic Biology … A cell is the basic building block of living things. All cells … to contain between 10 and 100 trillion cells. … A cell is the basic building block of living things. … …
Staff
Vence Bonham is the acting deputy director for NHGRI and an associate investigator in NHGRI's Social and Behavioral Research Branch.
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… health inequities. The Bonham group also studies sickle cell disease, a condition that will be impacted by emerging … populations. The Bonham group also studies sickle cell trait and sickle cell disease, a condition with applications …
Educational Resources
A stem cell is a cell with the potential to form many of the different cell types found in the body.
… Stem Cell … A stem cell is a cell with the potential to form many of the different cell types found in the body. … Cell, Mitosis … A stem cell …
News Release
The U.S. National Institutes of Health (NIH) has long invested in basic genetics and genomics research, clinical trials, as well as translational medicine and social science studies, to advance our understanding of this widespread illness to help develop effective therapies.
… (FDA) approved two gene therapies for the treatment of sickle cell disease in patients 12 years and older. About 100,000 … Americans and millions of people around the world have sickle cell disease , a hereditary disease common among those …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… complex that packages DNA into chromosomes in the cell - to better understand how the genome works. A better … are managed. … Chromatin influences gene activity in a cell by controlling access to the genes and regulatory … off. Chromatin organization can also influence both normal cell development - whether a cell might become a liver, …
Educational Resources
A phenotype is an individual's observable traits, such as height, eye color, and blood type.
… and blood type. … Gene, Heterozygous, Homozygous, Allele, Trait, Genotype … Phenotype refers to an individual’s …
Educational Resources
The plasma membrane, also called the cell membrane, is the membrane found in all cells that separates the interior of the cell from the outside environment.
… Plasma Membrane (Cell Membrane) … The plasma membrane, also called the cell membrane, is the membrane found in all cells that separates the interior of the cell from the outside environment. … Organelle, Nuclear …
News Release
A new study by scientists at NHGRI, suggests that iPSCs do not develop more mutations than cells that are duplicated by subcloning.
… developed the breakthrough technique to return any adult cell to its earliest stage of development (a pluripotent stem cell) and change it into different types of cells in the … doors to medical advances, including generating cartilage cell tissue to repair knees, retinal cells to improve the …