Search Results
Educational Resources
Gene amplification is an increase in the number of copies of a gene sequence.
… an increase in the number of copies of a gene sequence. … DNA Sequence, Cancer, PCR, Polymerase Chain Reaction, …
Clinical Research
This team-based clinical service os provided by NHGRI to Intramural Investigators employing exome/genome sequencing.
… NHGRI to Intramural Investigators employing exome/genome sequencing to accomplish their research goals. The SGFS will … NHGRI to Intramural Investigators employing exome/genome sequencing. … DNA Sequencing, Exam Sequencing, Genome Sequencing, Secondary …
Educational Resources
A plasmid is a small, often circular DNA molecule found in bacteria and other cells.
… Plasmid … A plasmid is a small, often circular DNA molecule found in bacteria and other cells. … Bacteria, … Deoxyribonucleic Acid (DNA), Gene, Cloning, DNA Sequencing, Genetic Engineering Recombinant DNA (rDNA) … A …
News Release
Scientists set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the cell - to better understand how the genome works.
… , scientists have set their sights on chromatin - the DNA-protein complex that packages DNA into chromosomes in the … They've combined several technologies, including DNA sequencing, and have gained insights into how genomic … with recent innovations in technologies to examine single cells. They labeled chromatin from thousands of cells, …
News Release
Scientists have published the first complete, gapless sequence of a human genome, two decades after the Human Genome Project produced the first draft human genome sequence.
… of the roughly 3 billion bases (or “letters”) in our DNA is critical for understanding the full spectrum of human … will empower genetic studies of human disease. The full sequencing builds upon the work of the Human Genome Project , … method can read up to 1 million DNA letters in a single read with modest accuracy, while the PacBio HiFi DNA …
The Genomics Landscape
In the January 2018 edition of The Genomics Landscape, NHGRI Director Eric Green features the NIH Intramural Sequencing Center.
… and the field of genomics. … The NIH Intramural Sequencing Center (NISC) sits on the top floor of a research … houses the Center's state-of-the-art, high-throughput DNA sequencing facility. In a rather modest start in 1997 … leadership of its Founding Director Eric Green, NISC began DNA sequencing with six ABI 377 instruments in lab space …
The Genomics Landscape
In the April 2018 edition of The Genomics Landscape, NHGRI Director Eric Green highlights the 15th anniversary of National DNA Day and the '15 for 15' Celebration.
… community will celebrate a yearly highlight - National DNA Day. On this day, students, teachers, and the public are … is the first topic, which was revealed today: DNA Sequencing. Advances in DNA sequencing technologies have … curated resource containing published data from studies on single-nucleotide polymorphism (or SNP) associations related …
News Release
Researchers sequence the genomes of healthy participants, then analyze the data to find presumed, mutations that might lead to a genetic condition.
… and bioinformatic challenges facing individualized genome sequencing in a clinical research setting. Once they … They have only recently been able to address it as DNA sequencing costs have plummeted. At this rate, just above … of how these mutations affect health. "We want to add DNA sequencing to the physician's toolbox," Dr. Biesecker …
Educational Resources
Northern blot is a laboratory technique used to detect a specific RNA sequence in a blood or tissue sample.
… … Northern Blot, Laboratory Experiment, RNA Sequence, DNA, Deoxyribonucleic Acid … Northern blot is a laboratory … matrix onto a solid membrane, which is then exposed to a DNA probe labeled with a radioactive, fluorescent or chemical … RNA fragments containing complementary sequences with the DNA probe sequence to be visualized within the Northern blot. …
The Genomics Landscape
In the July 2020 edition of The Genomics Landscape, NHGRI Director Eric Green recalls the White House event announcing the draft human genome sequence.
… billion letters of the four-letter (A, C, G, and T) human DNA instruction book. The first working draft and initial … had also accomplished a series of other goals, including sequencing the genomes of a set of model organisms. In fact, … for Inherited Disease Research (CIDR) High Throughput Sequencing and Genotyping Resource Access (X01) Limited …