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Cynthia Tifft, M.D., Ph.D. is the deputy clinical director for the National Human Genome Research Institute.
… by inhibiting activation of macrophage-derived microglial cells leading to neuronal apoptosis. This was the first … the Proia/Tifft team have generated induced pluripotent stem (iPS) cells from a patient with infantile Sandhoff … derived from Sandhoff disease-induced pluripotent stem cells exhibit impaired neurodifferentiation. J. Lipid …
Fact Sheets
A knockout mouse is a laboratory mouse in which researchers have inactivated an existing gene by replacing it or disrupting it with an artificial piece of DNA.
… disease.  … Researchers begin by harvesting embryonic stem (ES) cells from early-stage mouse embryos four days after … Mouse, Animal Model, Laboratory Experiment, DNA, Embryonic Stem Cells, Homologous Recombination … A knockout mouse is a …
Educational Resources
Cancer is a group of diseases characterized by uncontrolled cell growth.
… History … Cancer is a disease in which some of the body’s cells grow uncontrollably. There are many different types of …
Health FAQ
Discuss these questions with your doctor or health care provider.
… cell disease. The treatment may stop the sickling of cells and improve the lifespan of red blood cells . It may … The process used to prepare your body to receive modified stem cells is called conditioning. Chemotherapy helps make room in your bone marrow to receive the modified stem cells. Chemotherapy is given for a few days prior to …
Educational Resources
Centrioles are paired barrel-shaped organelles located in the cytoplasm of animal cells near the nuclear envelope.
… organelles located in the cytoplasm of animal cells near the nuclear envelope. … Cell Biology, Organelles, … organelles located in the cytoplasm of animal cells near the nuclear envelope. Centrioles play a role in … organelles located in the cytoplasm of animal cells near the nuclear envelope. … Educational Resources …
Educational Resources
Endoplasmic reticulum is a network of membranes inside a cell through which proteins and other molecules move.
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Cytoplasm is the gelatinous liquid that fills the inside of a cell. It is composed of water, salts, and various organic molecules.
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A tumor suppressor gene directs the production of a protein that is part of the system that regulates cell division.
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Mitosis is a cellular process that replicates chromosomes and produces two identical nuclei in preparation for cell division.
… by equal division of the cell’s content into two daughter cells that have identical genomes. … Mitosis is a cellular …
Educational Resources
Endoplasmic reticulum is a network of membranes inside a cell through which proteins and other molecules move.