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News Release
NIH researchers have created a data resource show how differences in an individual's genome can affect gene activity and contribute to disease.
… across all the tissues. "We didn't know how specific this regulation would be in different tissues," said … and Genomics Program at the Centre for Genomic Regulation in Barcelona, Spain, and his colleagues examined … Expression (GTEx) pilot analysis: Multitissue gene regulation in humans Science , May 7, 2015 Three other …
Staff
Dr. Shawn Burgess is the deputy director of NHGRI's Intramural Research Program.
… 2002. [ PubMed ] Wu X., Li Y., Crise B., Burgess S. Transcription start regions in the human genome are favored …
Staff
Dr. Bell is a senior investigator at the National Human Genome Research Institute's Cancer Genetics and Comparative Genomics Branch.
… truncating mutations in FOXA2, which encodes apioneer transcription factor that was not previously implicated in … DG, Goodfellow PJ, Mullikin JC, and Bell DW. The FOXA2 transcription factor is frequently somatically mutated in …
The Genomics Landscape
In the August 2019 edition of The Genomics Landscape, NHGRI Director Eric Green recognizes the recipients for the Presidential Early Career Award for Scientists and Engineers (PECASE), the highest honor given by the U.S. Government to outstanding scientists and engineers who are beginning their independent research careers.
… his pioneering approaches to the study of transcriptional regulation. By using a suite of new technologies, Dr. Sanjana …
File
… presenting this, I said, "Don't be surprised." You know, transcription from this perspective is, you know, is … there as one of these reproducible events. And not only transcription as in making RNA, but the passage of the …
Educational Resources
An intron is a portion of a gene that does not code for amino acids.
… not remain in the final mature mRNA molecule following transcription of that gene and does not code for amino acids …
Staff
Dr. Settara Chandrasekharappa is an associate investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… interaction with several different proteins, including the transcription factor JunD, and its requirement in endodermal …
News Release
NHGRI hosted two Pathway to Independance awardees and supported 18 additional investigators at institutions nationwide.
… Statistical Models to Investigate Long-Distance QTL Transcription Regulation Audrey Q. Fu, Ph.D., University of Chicago, Causal …
Staff
Dr. Francis Collins is a senior investigator in Center for Precision Health Research.
… P, Stitzel ML, Collins FS, Kitzman JO, Parker SCJ. A Transcription Start Site Map in Human Pancreatic Islets … Chromatin stretch enhancer states drive cell-specific gene regulation and harbor human disease risk variants . Proc … P, Freedman M, Siciliano MJ, Collins FS. Fusion between transcription factor CBF beta/PEBP2 beta and a myosin heavy …