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News Release
NIH researchers identified gene variants that cause a rare syndrome of sporadic fevers, skin rashes and recurring strokes, beginning early in childhood.
… adult onset stroke. They also induced ADA2 deficiency in a zebrafish animal model. They found that zebrafish embryos that produce less ADA2 than normal embryos … role for ADA2 protein is as a growth factor. Data from the zebrafish model suggest that this growth factor plays a role …
Staff
Dr. Tyra Wolfsberg is the associate director of the Bioinformatics and Scientific Programming Core at the National Human Genome Research Institute.
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… that are being used to inactivate every gene in the zebrafish genome, with the eventual goal of characterizing … TG, Pellegrini M, Burgess SM, Lin S. A large-scale zebrafish gene knockout resource for the genome-wide study of … J, Gildea DE, Yang Z, Wolfsberg TG, Lin S, Burgess SM. The Zebrafish Insertion Collection (ZInC): a web based, …
Policy Issues
Scientific institutions are developing recommendations to support the responsible use of human gene-editing research.
… multiple, simultaneous gene knockouts using CRISPR/Cas9 in zebrafish (Varshney, et al., 2015). The lab has also created … database called CRISPRz  that catalogs CRISPR targets in zebrafish. These target DNA sequences can be used by other …
Research at NHGRI
The Medical Genetics Branch studies inherited disorders of metabolism and of human development.
… development and use of experimental model systems, such as zebrafish and mouse. The Branch fosters outstanding basic …
Research Funding
The primary mission of the Alliance of Genome Resources (the Alliance) is to develop and maintain sustainable genome information resources that facilitate the use of diverse model organisms in understanding the genetic and genomic basis of human biology, health and disease. This understanding is fundamental for advancing genome biology research and for translating human genome data into clinical utility.
… namely, the Mouse Genome Database (MGD) , WormBase , Zebrafish Information Network (ZFIN) , Saccharomyces Genome … Xenbase Aaron Zorn, Ph.D., Cincinnati Children’s Hospital Zebrafish Information Network (ZFIN) Monte Westerfield, …
Research at NHGRI
The Metabolic Medicine Branch houses clinical and laboratory research programs that focus on the development of new therapies for patients with genetic disorders.
… use experimental systems, including stem cell, organoid, zebrafish and mouse models to mimic aspects of the conditions …
News Release
The largest genomic study on type 2 diabetes in Africans to date has recently been published in Nature Communications and reports the most recent findings of the ongoing Africa America Diabetes Mellitus (AADM) study that has been led by Dr. Charles Rotimi for over two decades.
… By conducting functional studies of this locus in zebrafish and mice, researchers discovered that ZRANB3 plays …
Policy Issues
Scientists have edited genomes for many years, but CRISPR technology has improved the speed, cost, accuracy, and efficiency of genome editing
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… research. Editing the genomes of yeast, bacteria, mice, zebrafish, and other organisms that scientists commonly study … (2015). High-throughput gene targeting and phenotyping in zebrafish using CRISPR/Cas9. Genome Research, 25(7), …
Profile
Jim Mullikin pioneered DNA sequencing technologies during the Human Genome Project and other major advances in genomics.
… important research organisms, such as mice, C. elegans and zebrafish. Throughout the Human Genome Project, Dr. Mullikin …
Staff
Dr. Settara Chandrasekharappa is an associate investigator in NHGRI's Cancer Genetics and Comparative Genomics Branch.
… positional cloning of mib, a gene in the Notch pathway in zebrafish. Mutations in mib result in increased neural … to neurons during embryonic development, leading to the zebrafish mind bomb phenotype. In a collaborative effort in … lab further investigated the expression of menin in mouse, zebrafish and drosophila development, and they also …