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Staff
Dr. Shawn Burgess is the deputy director of NHGRI's Intramural Research Program.
… of a large effort to develop insertional mutagenesis in zebrafish, coupled with a genetic screen to identify genes … on developing efficient gene knockout technologies in zebrafish, coupled with efficient phenotyping of the gene … the vertebrate model organisms mouse ( Mus musculus ) and zebrafish ( Danio rerio ) have also been sequenced, they …
Policy Issues
Genome editing is a method that lets scientists change the DNA of many organisms, including plants, bacteria, and animals.
… humans. They edit the genomes of animals, like mice and zebrafish, because animals have many of the same genes  as … just this. The Burgess lab , for example, is studying zebrafish genomes. Scientists in this lab delete different genes in zebrafish one at a time using CRISPR to see how the deletion …
News Release
Baylor College of Medicine. Houston and the Medical College of Wisconsin, Milwaukee will be providing DNA sequencing for the Undiagnosed Diseases Network.
… Principal Investigator: Shuo Lin, Ph.D. By developing a zebrafish model of undiagnosed disease genes, researchers … The researchers will make observations of the outcome in zebrafish from inserting mutations in genes that have a … Diane Slusarski, Ph.D. Researchers will use a zebrafish model to explore the function of 15 gene mutations …
Jobs at NHGRI
Funded postdoctoral positions are available in the laboratory of Dr. Shawn Burgess, within NHGRI's Translational and Functional Genomics Branch.
… wound healing with an emphasis on hearing regeneration in zebrafish. There are multiple projects available to pursue … flow cytometry, cytogenetics, and transgenic mouse and zebrafish cores, allowing for broad opportunities and wide … microscopy, genetics and genomics. Experience with zebrafish is a plus but not essential. Interest in and …
News Release
Researchers show critical association between diabetes and previously unlinked ZRANB3 gene.
… involved in T2D, the researchers studied its effects on zebrafish pancreas. The pancreas is one of the key organs … DNA editing system to make the ZRANB3 gene inoperative in zebrafish (called a ‘knockout’). They also used biological … to reduce the expression of the ZRANB3 gene in different zebrafish. In both cases, researchers observed a reduction in …
News Release
NIH recently awarded approximately $6.8 million in grants to several research teams to study the biology of rare and undiagnosed diseases.
… At the Model Organisms Screening Center, scientists use zebrafish and fruit flies as models to examine how … in UDN patients. Scientists genetically modify the zebrafish and fruit fly to study the gene variant in … gene variant or turn off the gene activity of a similar zebrafish or fly gene variant, and watch the resulting …
News Release
Scientists drafted the blueprint for how to build a common goldfish. Now they'll use it to find out what gives ornamental goldfish their nuanced features, gaining insight into human health.
… the National Human Genome Research Institute, works with zebrafish. He wanted to compare their genome to closely … genomes is not much better than comparing genomes between zebrafish and humans. So, Burgess and his friend honed in on … useful in comparative genomics and also add value to the zebrafish genome. So, his friend made an offer: I'll give you …
News Release
Four NHGRI researchers share the steps toward a career in genomics with 60 Brooklyn-area high school students.
… such as gene knockdown and gene sequencing in NHGRI's Zebrafish Core. He talked about zebrafish and why they are a good model for studying human …
News Release
Researchers have identified genomic mutations for Carey-Fineman-Ziter syndrome, a congenital myopathy with facial weakness, a cleft palate and scoliosis.
… Alessandro Di Gioia, Ph.D., and Dr. Engle, generated zebrafish with a mutated mymk gene. Affected mutant zebrafish were smaller and had abnormal muscle development … mutations. The researchers were able to correct affected zebrafish's muscles by injecting the normal human MYMK gene …
News Release
NHGRI has selected Sara Chandros Hull, Ph.D., and Shawn Burgess, Ph.D., as deputy scientific directors of NHGRI’s Intramural Research Program.
… has focused on understanding the function of genes in the zebrafish genome by developing and using efficient … to study genes associated with human deafness using the zebrafish as a model. Prior to joining NIH, Dr. Burgess …