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Associate Director

Office of Clinical Liaison

Associate Investigator

Medical Genetics and Genomic Medicine Training Program


B.S. Purdue University, 1976

M.S. University of California at Berkeley, 1981


Don Hadley obtained his bachelor's degree in agriculture from Purdue University and a master's degree in genetic counseling from the University of California at Berkeley. After completing his education, he joined the University of Wisconsin-Madison and worked as a genetic counselor within the Waisman Center, a university-affiliated program dedicated to the advancement of knowledge about human development, intellectual disabilities and neurodegenerative diseases. His work in Wisconsin included training and supervision of graduate students in genetic counseling, providing genetic counseling services to adult and pediatric populations experiencing genetic diseases, developing outreach programs throughout the state of Wisconsin and establishing counseling and support services for families with Huntington's disease.

In 1993, Mr. Hadley was invited to join a prestigious team of clinicians and scientists at the National Institutes of Health, and helped create and establish the National Center for Human Genome Research (now the National Human Genome Research Institute). He was tasked with creating an innovative graduate program in genetic counseling (as co-director) and establishing a research program exploring interest, uptake and outcomes associated with the provision of genetic testing. After 20 years at NIH, his work has expanded to 1) exploration of the challenges facing individuals and families being offered genomic sequencing technologies, and 2) helping to prepare the next generation of physicians training in genetic and genomic medicine.


Hadley D.W., Jenkins J., Dimond E., Nakahara K., Grogan L., Liewehr D.J., Steinberg S.M., Kirsch I. Genetic counseling and testing in families with hereditary non-polyposis colorectal cancer. Arch Intern Med, 163:573-582. 2003. [PubMed]

Hadley, D., Jenkins, J., deCarvalho, M., Dimond, E., Kirsch, I., Palmer, C.G.S. Colon cancer screening practices following genetic counseling and testing for hereditary non-polyposis colorectal cancer (HNPCC). Journal of Clinical Oncology, 22(1):39-44. 2004. [PubMed]

McInerney-Leo A., Biesecker B.B., Hadley D.W., Kase R.G., Giambarresi T.R., Johnson E, Lerman C., Struewing J.P. BRCA1/2 testing in hereditary breast and ovarian cancer families: effectiveness of problem-solving training as a counseling intervention. Am J Med Genet, 130A(3):221-7. 2004. [PubMed]

Wattendorf DJ, Hadley DW. Family History: The Three-Generation Pedigree. Amer Fam Physician, 72(3):441-448. 2005. [PubMed]

Lindor NM, Petersen GM, Hadley DW, Kinney AY, Miesfeldt S, Lu KH, Lynch P, Burke W. Press N. Recommendations for the care of individuals with an inherited
predisposition to Lynch Syndrome: A systematic review. JAMA, 296(12):1507-1517. 2006. [PubMed]

Doherty ES, Lacbawan F, Hadley DW, Brewer C, Zalewski C, Kim HJ, Solomon B, Rosenbaum K, Domingo DL, Hart TC, Brooks BP, Immken L, Lowry RB, Kimonis V, Shanske AL, Jehee FS, Bueno MR, Knightly C, McDonald-McGinn D, Zackai EH, Muenke M. Muenke Syndrome (FGFR3-Related Craniosynostosis): Expansion of the Phenotype and Literature Review. Am J Med Genet A, 143A(24):3204-15. 2007. [PubMed]

Hadley DW, Jenkins JF, Steinberg SM, Liewehr D, Moller S, Martin JC, Calzone KA, Soballe PW, Kirsch I. Perceptions of cancer risks and predictors of colon and endometrial cancer screening in women undergoing genetic testing for Lynch syndrome. J Clin Oncol, 26(6):948-954. 2008. [PubMed]

Shiloh S, Koehly L, Jenkins JF, Martin JC, Hadley DW. Monitoring coping style moderates emotional reactions to genetic testing for hereditary nonpolyposis colorectal cancer: a longitudinal study. Psychooncology, 17(8):746-55. 2008. [PubMed]

Ersig AL, Hadley DW, Williams J, Koehly LM. Communication, encouragement and cancer screening in families with and without mutations for hereditary nonpolyposis colorectal cancer: a pilot study. Genet Med, 11(10):728-34. 2009. [PubMed]

Lacbawan F, Soloman BD, Roessler E, et al. Clinical Spectrum of SIX3-Associated Mutations in Holoprosencephaly: Correlation between Genotype, Phenotype and Function. J Med Genet, 46(6):389-98. 2009. [PubMed]

Hadley DW, Ashida S, Jenkins JF, Mensz JM, Calzone KA, Kuhn NR, McBride CM, Kirsch IR, Koehly LM. Generation after generation: Exploring the psychological impact of providing genetic services through a cascading approach. Genet. Med, 12(12):808-815. 2010. [PubMed]

Raam MS, Pineda-Alvarez DE, Hadley DW, Solomon BD. Long-term outcomes of adults with features of VACTERL association. Eur J Med Genet, 54(1):34-41. 2011. [PubMed]

Hadley DW, Ashida S, Jenkins JF, Calzone KA, Kirsch IR, and Koehly LM. Colonoscopy use following mutation detection in Lynch syndrome: Exploring a role for cancer screening in adaptation. Clin Genet, 79(4):321-328. 2010. [PubMed]

Ashida S, Hadley DW, Goergen AF, Skapinsky K, Devlin H, Koehly LM. The importance of older family members in providing resources and promoting cancer screening in families with a hereditary cancer syndrome. Gerontologist, 51(6):833-42. 2011. [PubMed]

Solomon BD, Pineda-Alvarez DE, Hadley DW, NISC Comparative Sequencing Program, Teer JK, Cherukuri PF, Hansen NF, Cru z P, Young AC, Blakesley RW, Lanpher B, Mayfield Gibson S, Sincan M, Chandrasekharappa SC, Mullikin JC. Personalized genomic medicine: lessons from the exome. Mol Genet Metab, 104(1-2):189-91. 2011. [PubMed]

Solomon BD, Hadley DW, Pineda-Alvarez DE, NISC Comparative Sequencing Program, Kamat A, Teer JK, Cherukuri P, Hansen NF, Cruz P, Young AC, Berkman BE, Chandrasekharappa SC, Mullikin JC. Incidental Medical Information in Whole-Exome Sequencing. Pediatrics, 129(6):e1605-11. 2012. [PubMed]

Morris BA, Hadley DW, and Koehly LM. The role of religious and existential well-being in families with Lynch Syndrome: Prevention, family communication, and psychosocial adjustment to cancer. J Genet Counsel, DOI 10.1007/s10897-013-9571-9. 2014. [PubMed]

Shiloh S, Deheer H, Peleg S, Hensley Alford S, Skapinsky K, Roberts J, Hadley D. The Impact of Multiplex Genetic Testing on Disease Risk Perceptions. Clin Genet, doi: 10.1111/cge.12403. 2014. [PubMed]

Last updated: January 5, 2015