 |
|
Division of Intramural Research
|
Overview |
|
Vision, Mission and Values |
|
Organizational Chart |
|
Research Branches
|
|
Research Investigators
Profiles, publications, links |
|
Clinical Research
Clinical trials, patient recruitment, IRB, FAQ, Overview |
|
NHGRI Affiliated Centers
CIDR, CRGGH, NCGC, NISC
|
|
Online Research Resources Developed at NHGRI
Databases, software, tools, more. |
|
Division of Intramural Research Calendar
Workshops, conferences, seminar series, courses, more. |
|
Books and Publications |
|
|
|
In Other Sections:
|
|
 |
|
 |
Home Research Intramural Research
The Division of Intramural Research
 |
NHGRI's Division of Intramural Research plans and conducts a broad program of laboratory and clinical research to translate genomic and genetic research into a greater understanding of human genetic disease, and to develop better methods for the detection, prevention and treatment of heritable and genetic disorders. |
News and Events
 |
Numerous mutations in the human A-type lamin gene (LMNA)
cause the premature aging disease, progeria. Some of these are
located in the α-helical central rod domain required for the polymerization
of the nuclear lamins into higher order structures.
Patient cells with a mutation in this domain, 433G>A (E145K) show
severely lobulated nuclei, a separation of the A- and B-type lamins,
alterations in pericentric heterochromatin, abnormally clustered
centromeres, and mislocalized telomeres. The induction of lobulations
and the clustering of centromeres originate during postmitotic
nuclear assembly in daughter cells and this early G1 configuration
of chromosomes is retained throughout interphase. In vitro
analyses of E145K-lamin A show severe defects in the assembly of
protofilaments into higher order lamin structures. The results show
that this central rod domain mutation affects nuclear architecture
in a fashion distinctly different from the changes found in the most
common form of progeria caused by the expression of LA50/
progerin. The study also emphasizes the importance of lamins in
nuclear assembly and chromatin organization.
. [Full Text   ]
|
| |
 National Institutes of Health researchers, including members of the NIH Chemical Genomics Center, performed high-throughput chemical genomic screening to identify new leads for antimalarial drugs. A study published in the September 6, 2009 advance online edition of Nature Chemical Biology demonstrates the utility of the chemical genomics approach to studying malaria traits. [Full Text ]
|
|
New Date: 2009 Jeffrey M. Trent Lectureship in Cancer Research
Dr. Carol Greider, Daniel Nathans Professor and Director, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine. |
|
News Features from the Division of Intramural Research |
| |
The 2009 NHGRI Intramural Research Brochure (42Mb)  |
| |
Division of Intramural Research Tenure Track Positions |
|
Current Topics in Genome Analysis 2008 |
|
News and Events Archive |
|
NHGRI Event Webcasts |
|
To view the PDFs on this page you will need Adobe Reader.
Top of page
Last Updated: November 24, 2009
|
|
|
Genomics in Action
|
|
 |
|
K. J. Myung, Ph.D. won't just tell you about unstable genomes, he'll show you one. He studies genome instability, which is both a characteristic of and, in some cases, a trigger for many genetic diseases, including cancer. (more)
|
|
|
|
|
|
