Members of the Statistical Genetics Section of the National Human Genome Research Institute's Division of Intramural Research are co-authors of a study in the Aug. 31, 2014, advance online edition of Nature Genetics. In "Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma," researchers combined genetic data from 18 populations, including people of Asian and European descent, and identify ABCA1 as a risk gene for both high inner eye pressure and glaucoma. Glaucoma is a group of eye disorders that cause progressive damage to the optic nerve and can lead to permanent blindness. They also identified a link between two other genetic variants and both of these conditions.
Read the study: Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma
Researchers have discovered a new genetic association and innovative way of identifying genes involved in coronary artery calcification, a leading cause of heart disease and death. The team led by the National Human Genome Research Institute used a combination of RNA, DNA and protein analysis to identify the gene, TREML4. They learned about its biological role in the condition and demonstrated an alternative approach to large genome-wide association studies for discovering disease-associated genes. Their paper, "Integrative DNA, RNA, and Protein Evidence Connects TREML4 to Coronary Artery Calcification," appeared in the July 3, 2014, online issue of the American Journal of Human Genetics.
Read the study: Integrative DNA, RNA, and Protein Evidence Connects TREML4 to Coronary Artery Calcification
Last Updated: September 15, 2014