Research at NHGRI
The Division of Intramural Research conducts a broad program of laboratory and clinical research.
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Researchers Analyze First Complete DNA Sequence Generated at National Institutes of Health

NHGRI researchers gathered for a data annotation jamboree for the first ClinSeq whole genome sequenceA group of more than a dozen gene hunters from the National Human Genome Research Institute recently gathered at the National Institutes of Health Intramural Sequencing Center in Rockville, Md. to analyze data from the first complete DNA sequence of an NIH Clinical Center patient enrolled in the ClinSeqTM study. more

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New Date: 2009 Jeffrey M. Trent Lectureship in Cancer Research
Nobel prize winner Dr. Carol Greider, Daniel Nathans Professor and Director, Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, will speak on January 19th, 2010.

Current Topics in Genome Analysis 2010
Current Topics in Genome Analysis lecture series consists of lectures by local and outside speakers covering the major areas of genomics.

Highlights

P N A S Logo Numerous mutations in the human A-type lamin gene (LMNA) cause the premature aging disease, progeria. Some of these are located in the α-helical central rod domain required for the polymerization of the nuclear lamins into higher order structures. Patient cells with a mutation in this domain, 433G>A (E145K) show severely lobulated nuclei, a separation of the A- and B-type lamins, alterations in pericentric heterochromatin, abnormally clustered centromeres, and mislocalized telomeres. ... The results show that this central rod domain mutation affects nuclear architecture in a fashion distinctly different from the changes found in the most common form of progeria caused by the expression of LA50/progerin. [Full Text PDF file]

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Last Updated: December 17, 2009