Pu Paul Liu, M.D., Ph.D.
Senior Investigator, Genetics and Molecular Biology Branch
Head, Oncogenesis and Development Section
Deputy Scientific Director, NHGRI
Selected Publications
Kundu M, Javed A, Jeon J-P, Horner A, Shum L, Eckhaus M, Muenke M, Lian J, Yang Y, Nuckolls GH, Stein G, and Liu PP. Cbfβ interacts with Runx2 and has a critical role in bone development. Nature Genetics, 32: 639-644, 2002. [PubMed]
Lyons S, Lawson N, Lei L, Bennett P, Weinstein B, and Liu PP. A nonsense mutation in zebrafish gata-1 causes the bloodless phenotype in Vlad Tepes. Proc Natl Acad Sci USA 99:5454-5459, 2002. [PubMed]
Nishikawa K, Kobayashi M, Masumi A, Lyons LE, Weinstein BM, Liu PP and Yamamoto M. Self-association of GATA-1 enhances the transcriptional activity in zebrafish embryo. Mol Cell Biol, 23:8295-8305. 2003. [PubMed]
Castilla LH, Perrat P, Martinez NJ, Landrette S, Keys R, Oikemus S, Flanegan J, Garrett L, Dutra A, Pihan GA, Wolff L, Liu PP. Identification of genes that synergize with Cbfb-MYH11 in the pathogenesis of acute myeloid leukemia. Proc Natl Acad Sci USA, 101:4924-4929. 2004. [PubMed]
Kundu M, Compton S, Garrett-Beal L, Stacy T, Starost MF, Eckhaus M, Speck NA, Liu PP. Runx1 deficiency predisposes mice to T-lymphoblastic lymphoma. Blood, 106(10):3621-4. 2005. [PubMed]
Sood R., English, M.A., Jones, M., Mullikin, J., Wang, D.M., Anderson M., Wu, D., Chandrasekharappa, S.C., Yu, J., Zhang, J., and Liu, P.P. Methods for reverse genetic screening in zebrafish by resequencing and TILLING. Methods, 39(3):220-227. 2006. [PubMed]
Khan, A., Hyde, R.K., Dutra, A., Mohide, P., Liu, P. CBFB (core binding factor beta) haploinsufficiency due to an interstitial deletion at 16q21q22 resulting in delayed cranial ossification, cleft palate, congenital heart anomalies, and feeding difficulties but favourable outcome. Am J Med Genet A, 140(21):2349-54. 2006. [PubMed]
Zhao L, Cannons JL, Anderson S, Kirby M, Xu L, Castilla LH, Schwartzberg PL, Bosselut R, Liu PP. CBFB-MYH11 hinders early T-cell development and induces massive cell death in the thymus. Blood, 109:3432-40. 2007. [PubMed]
Belele C, English MA, Chahal J, Burnetti A, Finckbeiner SM, Gibney G, Kirby M, Sood R, and Liu PP. Differential requirement for gata1 DNA binding and transactivation between primitive and definitive stages of hematopoiesis in zebrafish. Blood, 114: 5162-72. 2009. [PubMed]
Hyde RK, Kamikubo Y, Anderson S, Kirby M, Alemu L, Zhao L, and Liu PP. Cbfb/Runx1-repression independent blockage of differentiation and accumulation of Csf2rb expressing cells by Cbfb-MYH11. Blood, 115: 1433-43. 2010. [PubMed]
Sood R, English MA, Belele C, Jin B, Bishop K, Haskins R, McKinney MC, Chahal J, Weinstein BM, Wen Z, and Liu PP. Development of multi-lineage adult hematopoiesis in the zebrafish with a runx1 truncation mutation. Blood, 115:2806-9. 2010. [PubMed]
Kamikubo Y, Zhao L, Wunderlich M, Corpora T, Hyde RK, Paul T, Kundu M, Garrett-Beal L, Compton S, Huang G, Wolff L, Ito Y, Bushweller J, Mulloy JC, and Liu PP. Accelerated leukemogenesis by truncated CBFb-SMMHC defective in high-affinity binding with RUNX1. Cancer Cell, 17:455-468. 2010. [PubMed]
Last Reviewed: May 23, 2011
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