Julie A. Segre, Ph.D.

Chief & Senior Investigator, Translational and Functional Genomics Branch
Head, Microbial Genomics Section

Selected Publications

Segre J.A, Nemhauser J.L, Taylor B.A., Nadeau J.H., Lander E.S.. Positional cloning of the nude locus: genetic, physical, and transcription maps of the region and mutations in the mouse and rat. Genomics, 28(3): 549-59. 1995. [PubMed]

Segre J.A., Bauer C., Fuchs E. Klf4 is a transcription factor required for establishing the barrier function of the skin. Nat Genet, 22(4): 356-60. 1999. [PubMed]

Fuchs E., Segre J.A. Stem cells: a new lease on life. Cell, 100(1): 143-55. 2000. [PubMed]

Jaubert J., Cheng J., Segre J.A. Ectopic expression of Kruppel like factor 4 (Klf4) accelerates formation of the epidermal permeability barrier. Development, (12):2767-77. 2003. [PubMed]

Segre J.A. Complex redundancy to build a simple epidermal permeability barrier. Current Opinion in Cell Biology, 15: 778-784. 2003. [PubMed]

Dai X., Segre J.A. Transcriptional control of epidermal specification and differentiation. Curr Opin Genet Dev, 14(5):485-91. 2004. [PubMed]

Jaubert J., Patel S., Cheng J., Segre J.A. Tetracycline-regulated transactivators driven by the involucrin promoter to achieve epidermal conditional gene expression. J Invest Dermatol, 123(2):313-8. 2004. [PubMed]

Martin, N., Patel, S. and Segre, J.A. Long-Range Comparison of Human and Mouse Sprr Loci to Identify Conserved Noncoding Sequences Involved in Coordinate Regulation. Genome Res, (12):2430-8. 2004. [PubMed]

Segre, J.A. Epidermal barrier formation and recovery in skin disorders. J. Clin. Invest. 2006; 116(5): 1150-8. [PubMed]

Segre, J.A. Epidermal Differentiation Complex yields a secret: Mutations in the cornification protein Filaggrin underlie ichthyosis vulgaris. J Invest Dermatol. 2006; 126(6):1202-4. [PubMed]

Patel, S., Xi, Z.F., Seo, E.Y., McGaughey, D., Segre, J.A. Klf4 and Corticosteroids Activate an Overlapping Set of Transcriptional Targets to Accelerate in utero Epidermal Barrier Acquisition. Proc Natl Acad Sci, 103(49):18668-73. 2006. [PubMed]

de Guzman Strong, C., Wertz, P.W., Wang, C., Yang, F. Meltzer, P.S., Andl, T., Millar, S.E., Ho, I.-C., Pai, S.-Y., and Segre, J.A. Defect Underlies Selective Barrier Deficiency of an Epidermal-specific Deletion of Gata-3. J Cell Biol, 175(4):661-70. 2006. [Full Text]

de Guzman Strong C, Segre JA. Navigating the genome. J Cell Sci, 1;121(Pt 7):921-3. 2008. [PubMed]

Scharschmidt TC, Segre JA. Modeling atopic dermatitis with increasingly complex mouse models. J Invest Dermatol, 128(5):1061-4. 2008. [PubMed]

Grice EA, Kong HH, Renaud G, Young AC; NISC Comparative Sequencing Program, Bouffard GG, Blakesley RW, Wolfsberg TG, Turner ML, Segre JA. A diversity profile of the human skin microbiota. Genome Res, 18(7):1043-50. 2008. [PubMed]

Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC; NISC Comparative Sequencing Program, Bouffard GG, Blakesley RW, Murray PR, Green ED, Turner ML, Segre JA. Topographical and temporal diversity of the human skin microbiome. Science, 324(5931):1190-2. 2009. [PubMed]

Scharschmidt TC, List K, Grice EA, Szabo R; NISC Comparative Sequencing Program, Renaud G, Lee CC, Wolfsberg TG, Bugge TH, Segre JA. Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota. J Invest Dermatol, 129(10):2435-42. 2009. [PubMed]

Kong HH, Segre JA. Bridging the translational research gap: a successful partnership involving a physician and a basic scientist. J Invest Dermatol, 130(6):1478-80. 2010. [PubMed]

de Guzman Strong C, Conlan S, Deming CB, Cheng J, Sears KE, Segre JA. A milieu of regulatory elements in the epidermal differentiation complex syntenic block: implications for atopic dermatitis and psoriasis. Hum Mol Genet, 15;19(8):1453-60. 2010. [PubMed]

Grice EA, Snitkin ES, Yockey LJ, Bermudez DM; NISC Comparative Sequencing Program, Liechty KW, Segre JA. Longitudinal shift in diabetic wound microbiota correlates with prolonged skin defense response. Proc Natl Acad Sci U S A, 107(33):14799-804. 2010. [PubMed]

Grice EA, Segre JA. The skin microbiome. Nat Rev Microbiol, 9(4):244-53. 2011. [PubMed]

Snitkin ES, Zelazny AM, Montero CI, Stock F, Mijares L; NISC Comparative Sequence Program, Murray PR, Segre JA. Proc Natl Acad Sci U S A, 108(33):13758-63. 2011. [PubMed]

Grice EA, Segre JA. Interaction of the microbiome with the innate immune response in chronic wounds. Adv Exp Med Biol, 946:55-68. 2012. [PubMed]

Kong HH, Segre JA. Skin microbiome: looking back to move forward. J Invest Dermatol, 132(3 Pt 2):933-9. 2012. [PubMed]

Kong HH, Oh J, Deming C, Conlan S, Grice EA, Beatson MA, Nomicos E, Polley EC, Komarow HD, NISC Comparative Sequence Program, Murray PR, Turner ML, Segre JA. Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis. Genome Res, 22(5):850-9. 2012. [PubMed]

Redford KH, Segre JA, Salafsky N, Del Rio CM, McAloose D. Conversion and the Microbiome. Conserv Biol, 26(2):195-197. 2012. [PubMed]

Structure, function and diversity of the healthy human microbiome. Human Microbiome Project Consortium. Nature, 486(7402):207-14. 2012. [PubMed

A framework for human microbiome research. Human Microbiome Project Consortium. Nature, 486(7402):215-21. 2012. [PubMed]

The Human Microbiome: Our Second Genome. Grice EA, Segre JA. Annu Rev Genomics Hum Genet, Epub ahead of print, 2012. [PubMed]

Staphylococcus epidermidis pan-genome sequence analysis reveals diversity of skin commensal and hospital infection-associated isolates. Conlan S, Mijares LA, Comp Seq Program N, Becker J, Blakesley RR, Bouffard GG, Brooks S, Coleman HL, Gupta J, Gurson N, Park M, Schmidt B, Thomas PJ, Young A, Otto M, Kong HH, Murray PR, Segre JA. Genome Biol, 13(7):R64. 2012. [PubMed]

Compartmentalized Control of Skin Immunity by Resident Commensals. Naik S, Bouladoux N, Wilhelm C, Molloy MJ, Salcedo R, Kastenmuller W, Deming C, Quinones M, Koo L, Conlan S, Spencer S, Hall JA, Dzutsev A, Kong H, Campbell DJ, Trinchieri G, Segre JA, Belkaid Y. Science, Jul 26, 2012. [PubMed]

Tracking a Hospital Outbreak of Carbapenem-Resistant Klebsiella pneumoniae with Whole-Genome Sequencing. Snitkin ES, Zelazny AM, Thomas PJ, Stock F; NISC Comparative Sequencing Program, Henderson DK, Palmore TN, Segre JA. Sci Transl Med, 4(148):148ra116. 2012. [PubMed]

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Last Updated: August 27, 2012