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Lawrence C. Brody, Ph.D.

Senior Investigator, Genome Technology Branch
Head, Molecular Pathogenesis Section

Selected Publications

Swanson DA, Liu ML, Baker PJ, Garrett L, Stitzel M, Wu J, Harris M, Banerjee R, Shane B, Brody LC. Targeted disruption of the methionine synthase gene in mice. Mol Cell Biol, 15:1058-1065. 2001. [PubMed]

Brody LC, Conley M, Cox C, Kirke PN, McKeever MP, Mills JL, Molloy AM, O'Leary VB, Parle-McDermott A, Scott JM, Swanson DA. A Polymorphism, R653Q, in the trifunctional enzyme methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase/formyltetrahydrofolate synthetase is a maternal genetic risk factor for neural tube defects: Report of the birth defects research group. Am J Hum Genet, 71(5):1207-15. 2002. [PubMed]

Brody LC. CHEKs and balances: Accounting for breast cancer. Nat Genet, 31(1):3-4. 2002. [PubMed]

Yarden RI, Pardo-Reoyo S, Sgagias M, Cowan KH and Brody LC. BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage. Nat Genet, 30(3):285-9. 2002. [PubMed]

Kanaan Y, Kpenu E, Utley K, Adams-Campbell L, Dunston GM, Brody LC, Broome C. Inherited BRCA2 mutations in African Americans with breast and/or ovarian cancer: a study of familial and early onset cases. Hum Genet, 113(5):452-60. 2003. [PubMed]

Coyne RS, McDonald HB, Edgemon K and Brody LC. Functional characterization of BRCA1 sequence variants using a yeast small colony phenotype assay. Cancer Biology and Therapy, 3:453-7. 2004. [PubMed]

Kirke PN, Mills JL, Molloy AM, Brody LC, O'Leary VB, Daly L, Murray S, Conley M, Mayne PD, Smith O, Scott JM. Impact of the MTHFR C677T polymorphism on risk of neural tube defects: case-control study. British Medical Journal, 328:1535-6. 2004. [PubMed]

Parle-McDermott A, Mills JL, Kirke PN, Cox C, Signore CC, Kirke S, Molloy AM, O'Leary VB, Pangilinan F,, O'Herlihy C, Brody LC and Scott JM. The MTHFD1 R653Q polymorphism is a maternal genetic risk factor for severe abruptio placentae. American Journal of Medical Genetics, 132:365-8. 2005. [PubMed]

Parle-McDermott A, Pangilinan FJ, Mills JL, Signore CC, Molloy AM, Cotter A, Conley M, Cox C, Kirke PN, Scott JM and Brody LC. A polymorphism in the MTHFD1 gene increases a mother's risk of having an unexplained second trimester pregnancy loss. Molecular Human Reproduction, 11:477-480. 2005. [PubMed]

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Last Reviewed: June 2, 2008