David M. Bodine, Ph.D

Chief & Senior Investigator, Genetics and Molecular Biology Branch
Head, Hematopoiesis Section

Selected Publications

Bodine DM, Birkenmeier CS, and Barker JE.  Spectrin deficient inherited hemolytic anemias in the mouse:  Characterization by spectrin synthesis and mRNA activity in reticulocytes.  Cell, 37:721-729. 1984. [PubMed]

Bodine DM and Ley TJ.  An enhancer element lies 3' to the human A gamma globin gene.  EMBO J, 6:2997-3004. 1987. [PubMed]

Bodine DM, Karlsson S, and Nienhuis AW.  The combination of Interleukin 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells.  PNAS, 86:8897-8901. 1989. [PubMed]

Bodine DM, McDonagh KT, Brandt SJ, Ney PA, Agricola B, Byrne E, Nienhuis AW.  Development of a high-titer retrovirus producer cell line capable of gene transfer into Rhesus hematopoietic stem cells.  PNAS, 87:3738-3742. 1990. [PubMed]

Orlic D, Anderson SM, Biesecker LG, Sorrentino BP, Bodine DM.  Pluripotent hematopoietic stem cells contain high levels of mRNA for c-kit, GATA-2, p45NF-E2 and c-myb, and low levels or no mRNA for c-fms and the receptors for granulocyte-colony stimulating factor and interleukins 5 and 7. PNAS, 92:4601-4605. 1995. [PubMed]

Orlic D, Girard LJ, Jordan CT, Anderson SM, Cline AP, Bodine DM. The level of mRNA encoding amphotropic retrovirus receptor in mouse and human hematopoietic stem cells is low and correlates with the efficiency of retrovirus transduction. PNAS, 93:11097-11012. 1996. [PubMed]

Dunbar CE, Seidel NE, Doren S, Sellers S, Cline AP, Metzger ME, Agricola BA, Donahue RE, Bodine DM. Improved retroviral gene transfer into murine and Rhesus peripheral blood or bone marrow repopulating cells primed in vivo with Stem Cell Factor and Granulocyte Colony Stimulating Factor. PNAS, 93:11871-76. 1996. [PubMed]

Sabatino DE, Cline AP, Gallagher PG, Garrett LJ, Stamatoyannopoulos G, Forget BG, Bodine DM. Substitution of the human beta-spectrin promoter for the human Ag-globin promoter prevents silencing of a linked b-globin gene in transgenic mice. Mol and Cell Biol, 18: 6634-6640. 1998. [PubMed]

Sabatino DE, Seidel NS, Aviles-Mendoza GJ, Cline AP, Anderson SM, Gallagher PG, Bodine DM. Long term expression of g-globin mRNA in mouse erythrocytes from retrovirus vectors containing the human g-globin gene fused to the Ank-1 promoter. PNAS, 97:13294-9. 2000. [PubMed]

Broxmeyer HE, Srour EF, Hangoc G, Cooper S, Anderson SM, Bodine DM. High Efficiency Recovery of Hematopoietic Progenitor Cells with Extensive Proliferative and Ex Vivo Expansion Activity and of Hematopoietic Stem Cells with NOD/SCID Mouse Repopulating Ability from Human Cord Blood Cryopreserved for 15 years. PNAS, 100:645-50. 2003. [PubMed]

Nemeth M, Kirby M, Bodine DM. Hmgb3 Regulates the Balance Between Hematopoietic Stem Cell Self-Renewal and Differentiation. PNAS, 103:13783-8. 2006.  [PubMed]

Nemeth MJ, Topol L, Kirby M, Yang Y, Bodine DM. Wnt5a Inhibits Canonical Wnt Signaling in Hematopoietic Stem Cells and Enhances Repopulation. PNAS, 104:15436-41. 2007. [PubMed]

Pilon AM, Arcasoy MO, Dressman HK, Vayda SE, Maksimova YD, Sangerman JI, Gallagher PG, Bodine DM. Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. Mol Cell Bio, 28(24):7394-401. 2008. [PubMed]

Laflamme K, Owen AN, Devlin EE, Yang MQ, Wong C, Steiner LA, Garrett LJ, Elnitski L, Gallagher PG, Bodine DM. Functional analysis of a novel cis-acting regulatory region within the human ankyrin gene (ANK-1) promoter. Mol Cell Biol, 30(14):3493-502. 2010. [PubMed]

Devlin EE, Dacosta L, Mohandas N, Elliott G, Bodine DM. A transgenic mouse model demonstrates a dominant negative effect of a point mutation in the RPS19 gene associated with Diamond-Blackfan anemia. Blood, 116:2826-35. 2010. [PubMed]

Gallagher PG, Steiner LA, Liem RI, Owen AN, Cline AP, Seidel NE, Garrett LJ, Bodine DM. Mutation of a barrier insulator in the human ankyrin-1 gene is associated with hereditary spherocytosis. J Clin Invest, 120:4453-65. 2010. [PubMed]

Pilon AM, Ajay SS, Kumar SA, Steiner LA, Cherukuri PF, Wincovitch S, Anderson SM; NISC Comparative Sequencing Center, Mullikin JC, Gallagher PG, Hardison RC, Margulies EH, Bodine DM. Blood, 118(17):e139-48. 2011. [PubMed]

Farrar JE, Vlachos A, Atsidaftos E, Carlson-Donohoe H, Markello TC, Arceci RJ, Ellis SR, Lipton JM, Bodine DM. Ribosomal Protein Gene Deletions in DBA. Blood, 118(26):6943-51. 2011. [PubMed]

Hogart A, Lichtenberg J, Ajay SS, Anderson S; NIH Intramural Sequencing Center, Margulies EH, Bodine DM. Genome-wide DNA methylation profiles in hematopoietic stem and progenitor cells reveal overrepresentation of ETS transcription factor binding sites. Genome Res, 22(8):1407-18. 2012. [PubMed]

Vlachos A, Farrar JE, Atsidaftos E, Muir E, Narla A, Markello TC, Singh SA, Landowski M, Gazda HT, Blanc L, Liu JM, Ellis SR, Arceci RJ, Ebert BL, Bodine DM, Lipton JM. Diminutive somatic deletions in the 5q region lead to a phenotype atypical of classical 5q- syndrome. Blood, 122: 2487-90. 2013. [PubMed]

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Last Updated: July 10, 2014