Ostrander Group

Elaine A. Ostrander, Ph.D.

Chief & NIH Distinguished Investigator, Cancer Genetics and Comparative Genomics Branch
Head, Comparative Genetics Section

Selected Publications:

Stanford JL, Just JJ, Gibbs M, Wicklund KG, Neal CL, Blumenstein BA, Ostrander EA. Polymorphic repeats in the androgen receptor gene: molecular marker of prostate cancer risk. Cancer Res, 57:1194-8. 1997. [PubMed]

Gibbs M, Stanford JL, McIndoe RA, Jarvik GP, Kolb S, Goode EL, Chakrabarti L, Schuster EF, Buckley VA, Miller EL, Brandzel S, Li S, Hood L, Ostrander EA. Evidence for a rare prostate cancer-susceptibility locus at chromosome 1p36. Am J Hum Genet, 64:776-87. 1999. [PubMed]

Guyon R, Lorentzen TD, Hitte C, Kim L, Cadieu E, Parker HG, Quignon P, Lowe JK, Renier C, Gelfenbeyn B, Vignaux F, DeFrance HB, Gloux S, Mahairas GG, André C, Galibert F, Ostrander EA. A 1-Mb resolution radiation hybrid map of the canine genome. Proc Natl Acad Sci U S A, 100:5296-301. 2003. [PubMed]

Lingaas F, Comstock KE, Kirkness EF, Sřrensen A, Aarskaug T, Hitte C, Nickerson ML, Moe L, Schmidt LS, Thomas R, Breen M, Galibert F, Zbar B, Ostrander EA. A mutation in the canine BHD gene is associated with hereditary multifocal renal cystadenocarcinoma and nodular dermatofibrosis in the German Shepherd Dog. Hum Mol Genet, 12:3043-53. 2003. [PubMed]

Parker HG, Kim LV, Sutter NB, Carlson S, Lorentzen TD, Malek TB, Johnson GS, DeFrance HB, Ostrander EA, Kruglyak L. Genetic structure of the purebred domestic dog. Science, 304:1160-4. 2004. [PubMed]

Sutter NB, Eberle MA, Parker HG, Pullar BJ, Kirkness EF, Kruglyak L, Ostrander EA. Extensive and breed specific linkage disequilibrium in Canis familiaris. Genome Res, 12:2388-96. 2004. [PubMed]

Stanford JL, McDonnell SK, Friedrichsen DM, Carlson EE, Kolb S, Deutsch K, Janer M, Hood L, Ostrander EA, Schaid DJ. Prostate cancer and genetic susceptibility: a genome scan incorporating disease aggressiveness. Prostate, 66:317-25. 2006. [PubMed]

Mosher DS, Quignon P, Bustamante CD, Sutter NB, Mellersh CS, Parker HG, Ostrander EA. A mutation in the myostatin gene increases muscle mass and enhances racing performance in heterozygote dogs. PLoS Genetics 5, 3(5):e79. 2007. [PubMed]

Sutter NB, Bustamante CD, Chase K, Gray MM, Zhao K, Zhu L, Padhukasahasram B, Karlins E, Davis S, Jones PG, Quignon P, Johnson GS, Parker HG, Fretwell N, Mosher DS, Lawler DF, Satyaraj E, Nordborg M, Lark KG, Wayne RK, Ostrander EA. A Single IGF1 Allele is a Major Determinant of Small Size in Dogs . Science, 316(5821):112-5. 2007. [PubMed]

Parker HG, vonHoldt BM, Quignon P, Margulies EH, Shao S, Mosher DS, Spady TC, Elkahloun A, Cargill M, Jones PG, Maslen CL, Acland GM, Sutter NB, Kuroki K, Bustamante CD, Wayne RK, Ostrander EA. An expressed Fgf4 retrogene is associated with breed-defining chondrodysplasia in domestic dogs. Science, 325:995-8. 2009. [PubMed]

Malone, K.E., Daling, J.R., Doody, D.R., Hsu, L., Bernstein, L., Coates, R.J, Marchbanks, P.A., Simon, M.S., McDonald, J.A. Norman, S.A. Strom, B.L., Burkman, R.T., Ursin, G., Deapen, D., Weiss, L.K., Folger, S.F., Madeoy J.J., Friedrichsen, D.F., Suter, N.M., Humphrey, M.C,. Spirtas R., Ostrander E.A. Prevalence and predictors of BRCA1 and BRCA2 mutations in a population-based study of breast cancer in white and black American women ages 35 to 64 years. Cancer Research, 66:8297-308. 2006. [PubMed]

Khanna, C., Lindblad-Toh, L., Vail, D., London, C., Bergman, P., Barber, L., Breen, M., Kitchell, B., McNeil, E., Modiano, J.F., Niemi, S., Comstock, K.E., Ostrander, E., Westmoreland, S., Withrow S. The dog as a cancer model. Nature Biotechnol, 24:1065-6. 2006. [PubMed]

Suuriniemi, M., Aaliu I., Schaid D.J., Johanesson, B., McDonell, S.K., Iwasaki L., Stanford J.L., Ostrander E.A. Confirmation of a positive association between prostate cancer risk and a locus at chromosome 8q24. Cancer Epi Biomarkers, 16(4):809-14. 2007. [PubMed]

Schaid D.J., Stanford J.L., McDonnell, S.K., Suuriniemi M., McIntosh, L., Karyadi, D.M., Carlson E., Deutsch K., Janer M., Hood L. Ostrander E.A. Genome-wide linkage scan of prostate cancer Gleason score and confirmation of chromosome 19q. Hum. Genetics, 121:729-35. 2007. [PubMed]

Parker H.G., Kukekova A.V., Akey D.T., Goldstein O., Kirkness E. F., Baysac K.C., Mosher D.S., Aguirre G.D. Acland G.M., Ostrander E.A. Breed relationships facilitate fine mapping studies: A 7.8 Kb deletion cosegregates with collie eye anomaly across multiple dog breeds. Genome Research, 17:1562-1571. 2007. [PubMed]

Wayne, R.K., Ostrander E.A. Lessons learned from the dog genome. Trends In Genetics, 23:557-67. 2007. [PubMed]

Johanneson B., McDonnell S.K., Karyadi D.M., Hebbring, S.J., Wang L., Deutsch K., McIntosh L., Kwon E.M., Suuriniemi M., Stanford J.L., Schaid D.J., Ostrander E.A., Thibodeau S.N. Fine-mapping of hereditary prostate cancer families narrows the interval for a susceptibility locus on chromosome 22q12.3 to 1.36 Mb. Human Genetics, 123:65-75. 2007. [PubMed]

Jones P., Chase K., Martin A., Ostrander E.A. Lark K.G. SNP-Based association mapping of dog stereotypes. Genetics, 179:1033-44. 2008. [PubMed]

Holt S.K., Karyad D.M., Kwon E.M., Stanford J.L., Nelson P.S., Ostrander E.A. Association of megalin genetic polymorphisms with prostate cancer risk and prognosis. Clinical Cancer Research, 15:3823-31. 2008. [PubMed]

FitzGerald L.M., Kwon E.M., Koopmeiners J.S., Salinas C.A., Stanford J.L., Ostrander E.A. Analysis of recently identified prostate cancer susceptibility loci in a population-based study: Associations with family history and clinical features. Clinical Cancer Research, 5:3231-7. 2009. [PubMed]

Stanford J.L., FitzGerald L.M., McDonnell S.K., Carlson E.E., McIntosh L.M., Deutsch K., Hood L., Ostrander E.A., Schaid D.J. Dense genome-wide SNP linkage scan in 301 hereditary prostate cancer families identifies multiple regions with suggestive evidence for linkage. Human Molecular Genetics, 18:1839-1848. 2009. [PubMed]

Parker H.G., Von Holdt B.M., Quignon P., Margulies E.H., Shao S., Mosher D.S., Spady T.C. Cargill M., Jones, P.G., Maslen, C.L., Acland, G.M., Sutter, N.B., Cook J.L., Bustamante, C.D., Wayne, R.K., Ostrander E.A. Wayne R.K., Ostrander E.A. An expressed Fibroblast Growth Factor 4 (fgf4) retrogene is associated with breed-defining chondrodysplasia in the domestic dog. Science, 325:995-8. 2009. [PubMed]

Cadieu E, Neff MW, Quignon P, Walsh K, Chase K, Parker HG, vonHoldt BM, Rhue A, Boyko A, Byers A, Wong A, Mosher DS, Elkahloun AG, Spady TC, André C, Lark KG, Cargill M, Bustamante CD, Wayne RK, Ostrander EA. Coat variation in the domestic dog is governed by variants in three genes. Science, 326:150-3. 2009. [PubMed]

Boyko AR, Quignon P, Li L, Schoenebeck JJ, Degenhardt JD, Lohmueller KE, Zhao K, Brisbin A, Parker HG, vonHoldt BM, Cargill M, Auton A, Reynolds A, Elkahloun AG, Castelhano M, Mosher DS, Sutter NB, Johnson GS, Novembre J, Hubisz MJ, Siepel A, Wayne RK, Bustamante CD, Ostrander EA. A simple genetic architecture underlies morphologic variation in dogs. PLoS Biol, 8:e1000451. 2010. [PubMed]

vonHoldt BM, Pollinger JP, Lohmueller KE, Han E, Parker HG, Quignon P, Degenhardt JD, Boyko AR, Earl DA, Auton A, Reynolds A, Bryc K, Brisbin A, Knowles JC, Mosher DS, Spady TC, Elkahloun A, Geffen E, Pilot M, Jedrzejewski W, Greco C, Randi E, Bannasch D, Wilton A, Shearman J, Musiani M, Cargill M, Jones PG, Qian Z, Huang W, Ding ZL, Zhang YP, Bustamante CD, Ostrander EA, Novembre J, Wayne RK. Genome-wide SNP and haplotype analyses reveal a rich history underlying dog domestication. Nature, 464: 898-902. 2010. [PubMed

Kwon EM, Salinas CA, Kolb S, Fu R, Feng Z, Stanford JL, Ostrander EA. Genetic polymorphisms in inflammation pathway genes and prostate cancer risk. Cancer Epidemiol Biomarkers Prev, 20:923-33. 2011. [PubMed]

Shearin AL, Hedan B, Cadieu E, Erich SA, Schmidt EV, Faden DL, Cullen J, Abadie J, Kwon EM, Gröne A, Devauchelle P, Rimbault M, Karyadi DM, Lynch M, Galibert F, Breen M, Rutteman GR, André C, Parker HG, Ostrander EA. The MTAP-CDKN2A locus confers susceptibility to a naturally occurring canine cancer. Cancer Epidemiol Biomarkers Prev, 21:1019-27. 2012. [PubMed]

Schoenebeck JJ, Hutchinson SA, Byers A, Beale HC, Carrington B, Faden DL, Rimbault M, Decker B, Kidd JM, Sood R, Boyko AR, Fondon JW 3rd, Wayne RK, Bustamante CD, Ciruna B, Ostrander EA. Variation of BMP3 contributes to dog breed skull diversity. PLoS Genet, 8:e1002849. 2012. [PubMed]

Ostrander EA. Franklin H. Epstein Lecture. Both ends of the leash--The human links to good dogs with bad genes. New Engl J Med, 367:636-46. 2012. [PubMed]

Rimbault M, Beale HC, Schoenebeck JJ, Hoopes BC, Allen JJ, Gilroy-Glynn P, Wayne RK, Sutter NB, Ostrander EA.  Derived variants at six genes explain nearly half of size reduction in domestic dogs.  Genome Research, 23:1985-95. 2013. [PubMed Central]

Karyadi DM, Karlins E, Decker B, vonHoldt BM, Carpintero-Ramirez G, Parker HG, Wayne RK, Ostrander EA. A copy number variant at the KITLG locus likely confers risk for canine squamous cell carcinoma of the digit. PLoS Genetics, 9:e1003409. 2013. [PubMed]


Parker, H.G., Sutter, N.B., Ostrander E.A.: Understanding genetic relationship among purebred dogs: The PhyDo Project. In: E.A. Ostrander, K. Lindbland-Toh, Urs Giger, (eds). The Dog and Its Genome. Cold Spring Harbor Press. 2006.

Hitte C., Kirkness E.F., Ostrander, E.A. Galibert, F.: Survey sequencing and radiation hybrid mapping to construct comparative maps. In: W. Murphy (ed). Methods in Molecular Biology: Phylogenomics. Humana Press, 2006.

Ostrander E.A., and Wayne R.K. The Canine Genome. In: H. Sussman and M.A. Smit, (eds.) Genomes. Cold Spring Harbor Press. 275 pp. 2006.

Every dog has its day: An overview of the recent advances in canine genetics. In: C. Kole & Noelle E. Cockett (eds.). Genome Mapping in Animals. Springer-Verlag. [In Press]

Ostrander E.A., Parker, H.G., and Sutter N.B. Canine Genetics Facilitates Understanding of Human Biology. In: 2006 Stadler Symposium. St. Louis. 2006. [In Press].

Ostrander E.A. and Parker H.G. Human genetics and the canine system. In: F. Vogel, A. Motulsky, S, Antonarakis and M. Speicher. (eds.) Human Genetics: Principals and Approaches. 4th Edition. Springer Publishing. 2007 [In Press].

Ostrander, E.A., and Johannesson, B. Hormonal Carcinogenesis III. In: Li, J.J., and Li, S.A. (eds.) Springer-Verlag. 2007. [In Press].

Lindblad-Toh, K. and Ostrander, E.A. Canine genetics and genome variation. In: S. Gabriel, J.C. Stephens and M. Weiner (eds.) Genetic Variation: A Laboratory Manual. Cold Spring Harbor Press. 2007. [In Press].

Ostrander E.A. and Karyadi, D.M. Genetic factors: Finding cancer susceptibility genes. In: Abeloff M.D., Armitage J.O, Niederhuber J.E., Kastan M.B. and McKenna W.G. (eds): Abeloff's Clinical Oncology, 4th ed. Elsevier Science, Philadelphia PA, pp. 193-205. 2008.

Hitte C., Kirkness E.F., Ostrander E.A. Galibert F. Survey sequencing and radiation hybrid mapping to construct comparative maps. In: Methods in Molecular Biology: Phylogenomics, Editor: W. Murphy. Humana Press. Series Editor: J. Walker. pp. 65-77. 2008

Ostrander, E.A., and Johanneson, B. Prostate cancer susceptibility loci: Finding the genes. In: Hormonal Carcinogenesis V. Li, J.J., Li, S.A., Mohla, S., Rochefort, H., Maudelonde, T., (eds.) Volume 617, Springer-Verlag, New York pp. 179-190. 2008.

Potter, J. D. and Lindor N.M. Genetics of Colorectal Cancer; in Cancer Genetics, Series Editor: Ostrander, E,A., Springer Science + Business Media and Humana Press, New York, NY. 2008.

Mosher, D.S., Spady, T.C., Ostrander E.A. Every dog has its day: An overview of the recent advances in canine genetics. In: Genome Mapping and Genomics in Animals, Volume 3, Eds: C. Kole & N. E. Cockett, Springer-Verlag Berlin Heidelberg, New York, Tokyo Chapter 8, pp. 231-256. 2009.

Ostrander E.A., Parker, H.G., and Sutter N.B. Canine Genetics Facilitates Understanding of Human Biology in: 2006 Stadler Symposium. St. Louis. 2009. 

Ostrander E.A. and Parker H.G. Human genetics and the canine system in: Human Genetics: Principals and Approaches 4th Edition, Eds: F. Vogel, A. Motulsky, S, Antonarakis and M. Speicher. Springer Publishing. 2009. 

Welcsh, P. (Editor). The Role of Genetics in Breast and Reproductive Cancers; in Cancer Genetics, Series Editor: Ostrander, E, A., Springer Science + Business Media and Humana Press, New York, NY. 2009. 

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Last Updated: June 26, 2014