Edward Giniger, Ph.D.

Adjunct Investigator, Genetics and Molecular Biology Branch
Senior Investigator, National Institute of Neurological Disorders and Stroke [ninds.nih.gov]

Selected Publications

Giniger, E. How do Rho family GTPases direct axon growth and guidance? A proposal relating signaling pathways to growth cone mechanics. Differentiation, 70: 385-396. 2002. [PubMed]

Crowner, D., Madden, K., Goeke, S. and Giniger, E. Lola regulates midline crossing of CNS axons in Drosophila. Development, 129: 1317-1325. 2002. [PubMed]

Crowner, D., Le Gall, M., Gates, M.A. and Giniger, E. Notch steers Drosophila ISNb motor axons by regulating the Abl signaling pathway. Curr Biol, 13: 967-972. 2003. [PubMed]

Goeke, S., Greene, E.A., Gates, M.A., Grant, P.K., Crowner, D., Aigaki, T. and Giniger, E. Alternative splicing of lola generates 19 transcription factors controlling axon guidance in Drosophila. Nature Neuroscience, 6: 917-924. 2003. [PubMed]

Horiuchi, T. Giniger, E. and Aigaki, T. Alternative trans-splicing of constant and variable exons of a Drosophila axon guidance gene, lola. Genes, Dev 17: 2496-2501. 2003. [PubMed]

Le Gall, M. and Giniger, E. Identification of two binding regions for the Suppressor of Hairless protein within the intracellular domain of Drosophila Notch. J. Biol. Chem, 279: 29418-29426. 2004. [PubMed]

Connell-Crowley, L., Vo, D., Luke, L., Giniger E. Drosophila lacking the Cdk5 activator, p35, display defective axon guidance, age-dependent behavioral deficits and reduced lifespan. Mech of Dev, 124(5):341-9. 2007. [PubMed]

Spletter, M.L., Liu, J., Liu, J., Su, H., Giniger, E., Komiyama, T. Quake, S. and Luo, L. Lola regulates Drosophila olfactory projection neuron identity and targeting specificity. Neural Develop, 2: 14. 2007. [PubMed]

Le Gall, M., DeMattei, C. and Giniger, E. Molecular separation of two signaling pathways for the receptor, Notch." Dev. Biol, 313:556-567. 2008. [PubMed]

Song, J.K., Giniger, E. and Desai, C.J. The receptor tyrosine phosphatase PTP69D antagonizes Abl tyrosine kinase to guide axons in Drosophila. Mech of Dev, 125:247-256. 2008. [PubMed]

J.K. Song, R. Kannan, G. Merdes, J. Singh, M. Mlodzik and E. Giniger. Disabled is a bona fide component of the Abl signaling network. Development. 137(21):3719-27. [PubMed]

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Last Updated: March 11, 2014