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National Advisory Committee for Human Genome Research

Director's Report Related Documents: September 2007

Announcements

• Maynard Olson Receives the 2007 Gruber Prize for Genetics
• Marco Marra Elected to RSC: The Academies of Arts, Humanities and Sciences of Canada

New NHGRI Initiatives

ENCODE

• RFA-HG-07-010: A Data Analysis Center for the Encyclopedia of DNA Elements (ENCODE) Project (U01)

Genes and Environment Initiative (GEI)

• RFA-MH-08-040: Methods of Statistical Analysis of DNA Sequence Data for Studies Relating Variation to Disease (R01)
• RFA-HG-07-012: Genome-Wide Association Studies in the Genes, Environment and Health Initiative - Study Investigators (U01)
• RFA-HG-07-014: Epidemiologic Investigation of Putative Causal Genetic Variants-Study Investigators (U01)
• RFA-HG-07-015: Epidemiologic Investigation of Putative Causal Genetic Variants-Coordinating Center (U01)

Recent News Releases

• Study to Probe How Healthy Younger Adults Make Use of Genetic Tests
• Mouse Model Points to Possible New Strategy for Treating Rare Muscle Disease, Kidney Disorders
• Journal of Clinical Investigation: Mutation in the key enzyme of sialic acid biosynthesis causes severe glomerular proteinuria and is rescued by N-acetylmannosamine
• New Findings Challenge Established Views on Human Genome
• NIH Awards Nearly $5 Million to Fund Knockout Mouse Repository
• The Cancer Genome Atlas Awards Funds for Technology Development
• New Grants Bolster Efforts to Generate Faster and Cheaper Tools for DNA Sequencing
• NHGRI Funds Two Centers of Excellence in Genomic Science
• New Director to Advance Computational Biology Efforts

Recent Articles

ENCODE

All articles are from Genome Research and are open access.

• Pseudogenes in the ENCODE regions: Consensus annotation, analysis of transcription, and evolution
• The ENCODEdb portal: Simplified access to ENCODE Consortium data
• Identification of higher-order functional domains in the human ENCODE regions
• The DART classification of unannotated transcription within the ENCODE regions: Associating transcription with known and novel loci
• What is a gene, post-ENCODE? History and updated definition
• A framework for collaborative analysis of ENCODE data: Making large-scale analyses biologist-friendly
• Statistical analysis of the genomic distribution and correlation of regulatory elements in the ENCODE regions
• Finding cis-regulatory elements using comparative genomics: Some lessons from ENCODE data
• Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions

Molecular Libraries Screening Network

• Neurobiology of Disease: Differentiating Alzheimer Disease-Associated Aggregates with Small Molecules
• PNAS: Three classes of glucocerebrosidase inhibitors identified by quantitative high-throughput screening are chaperone leads for Gaucher disease
• Nature: Reporting data from high-throughput screening of small-molecule libraries
• Nature: Image-based chemical screening

Zebrafish Knockout Bank

• genome.gov Web Feature: Process Paves Way for Zebrafish Knockout Bank
• Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions

Population Genomics

• NHGRI Office of Population Genomics Cohort Study Summary Table
• Science: Identifiability in Genomic Research
• NOT-OD-07-088 [grants.nih.gov]: Policy for Sharing of Data Obtained in NIH Supported or Conducted Genome-Wide Association Studies (GWAS)
• Nature: New models of collaboration in genomewide association studies: the Genetic Association Information Network

Genetic Information Nondiscrimination Act (GINA) Update

• Nature: U.S. Genetics Bill Blocked Again

Sequencing Status Update

• Organism Sequencing Status Update

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Last Updated: March 13, 2012