Large-Scale Genome Sequencing and Analysis Centers (LSAC)

Program Rationale

The scope and purpose of the Large-Scale sequencing component of the NHGRI Genome Sequencing Program will be as described in the original solicitation (RFA HG 10-015), and on an evolving continuum with the previous goals and polices. The program will pursue significant biomedical questions that can be addressed by sequencing at large scale, including cancer, complex disease, questions about basic genomic variation and how it relates to biology and disease, basic questions in comparative genomics, a and others. The renewed program will also emphasize the increasingly challenging issue of identifying and designing new project types that address the most compelling new questions that can be answered as high throughput sequencing continues to evolve, and also the increasingly challenging bioinformatics and integration issues that attend such studies. During the next four years, NHGRI anticipates that the type and number of important large-scale sequencing products will continue to expand, requiring new flexibility from this component of the program.

Because of the changing scope and nature of the kinds of compelling projects that these centers will undertake, the mechanisms for identifying new projects will continue to change over time. NHGRI will complete all projects that have already been initiated under the previous program. Information about ongoing projects is available at. Policies for data deposition and data access have not changed.

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Grantees of the Program

The currently funded centers are:

  • Baylor College of Medicine, Houston, TX
  • The Broad Institute , Cambridge, MA
  • Washington University, St. Louis MO

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Program Contacts

Adam Felsenfeld, Ph.D.
Program Director

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Last Updated: November 26, 2012