Research Funding
The Extramural Research Program provides scientific administration and management...more
Researchers working at an NHGRI-supported large-scale sequencing center. Courtesy: The Broad Institute of MIT and Harvard

ClinGen setting standards for when genes and their variants matter in disease

Read more In a special report appearing online May 27, 2015, in the New England Journal of Medicine, investigators with the National Institutes of Health's Clinical Genome Resource (ClinGen) describe how the program is evaluating the clinical relevance of genomic variants for use in precision medicine and research. ClinGen, launched in 2013, is funded by the National Human Genome Research Institute (NHGRI), with co-funding from the Eunice Kennedy Shriver National Institute of Child Health and Human Development and the National Cancer Institute, all part of NIH. Read more

GTEx findings reveal new insights into how DNA differences influence gene activity, disease susceptibility

Read more Bethesda, Md., Thurs., Mar. 7, 2015 - Researchers funded by the National Institutes of Health Genotype-Tissue Expression (GTEx) project have created a new and much-anticipated data resource to help establish how differences in an individual's genomic make-up can affect gene activity and contribute to disease. Read more 


Featured Grants

  • Centers for Common Disease Genomics (UM1)
    RFA-HG-15-001 []
    Application Receipt Date(s): April 07, 2015
    Expiration Date: April 8, 2015

New view of RNA may help in understanding gene controls

Nature Genetics coverRibonucleic acid (RNA) transmits genetic information from DNA to the cell's protein-producing machinery. RNAs adopt specific physical structures to control when genes are turned on and off. Scientists have now devised a way to view RNA structures in living cells. The new approach, developed at Stanford University with NHGRI support, may greatly improve understanding of gene regulation in biology and medicine.
Read the paper: Structural imprints in vivo decode RNA regulatory mechanisms. Nature, March 18,  2015.

Genome regions linked to BMI and fat distribution

Feet standing on a scaleResearchers have linked multiple new regions of the human genome to body mass index (BMI) and fat distribution, according to two studies just published in Nature. Population Architecture using Genomics and Epidemiology Consortium scientists supported by the National Human Genome Research Institute contributed to the studies that may lead to more effective therapeutic targets. Read more at 


Last Updated: May 27, 2015