Research at NHGRI
The Division of Intramural Research conducts a broad program of laboratory and clinical research.

Fearfulness changes impact of genomic information in overweight women

Read more New research suggests that fearful patients who received information about the role of genomics in being overweight viewed the information as threatening and were less likely to take steps to improve their health habits than those in a neutral or angry state. The study, by researchers from the National Institutes of Health (NIH) and NHGRI's Social and Behavioral Research Branch was published in an advanced online issue of the Annals of Behavioral Medicine on February 5, 2016. Read more

T-cell transcription factor may offer new pathway for vaccine research

Read moreThe gold standard for a successful vaccine is the creation of long-lasting antibodies that will defend the body against disease for years. Now, a team headed by scientists at the National Human Genome Research Institute (NHGRI) has found a promising new area for vaccine developers to explore in search of that gold. The new discovery involves a protein called a transcription factor - a molecular switch that turns a gene or a cascade of genes on or off. Read more

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NIH researchers identify striking genomic signature shared by five types of cancer

A conceptual depiction of red blood cells interspersed with DNA double helices and flags representing DNA methylation. DNA methylation is a chemical modification of DNA called methylation, which can control the expression of genes like a dimmer on a light switch. The image also includes a test tube of blood because researchers hope this finding will spur development of a blood test that can be used to diagnose a variety of cancers at early stages.National Institutes of Health researchers have identified a signature in tumor DNA that occurs in five different types of cancer. They also found evidence that this methylation signature may be present in many more types of cancer. The specific signature results from a chemical modification of DNA called methylation. Researchers hope to spur development of a blood test that can be used to diagnose a variety of cancers at early stages. The study appeared February 5, 2016, in The Journal of Molecular Diagnostics. Read more

Undiagnosed Diseases Network launches online application portal

Read moreThe Undiagnosed Diseases Network (UDN), a clinical research initiative of the National Institutes of Health (NIH), has opened an online patient application portal called the UDN Gateway. Introduction of this application system sets the stage for the network to advance its core mission: to diagnose patients who suffer from conditions that even skilled physicians have been unable to diagnose despite extensive clinical investigation. Read more

Postdoctoral Positions in the Computational and Statistical Genomics Branch New
Adam Phillippy, Ph.D.

Last Updated: February 8, 2016