Research at NHGRI
The Division of Intramural Research conducts a broad program of laboratory and clinical research.

Investigating why cancer comes back

Read moreFor a patient with cancer, two of the most important words in the oncologist's lexicon begin with the letter "r": remission and relapse. Why do some patients stay in remission, while others see their cancer return? In recent research published online in July in the journal Leukemia, Paul Liu, M.D., Ph.D., a senior investigator, and Raman Sood, Ph.D., an associate investigator, for the Translational and Functional Genomics Branch at NHGRI, are trying to understand why leukemia patients relapse, and if there are any DNA-level mutations that account for the leukemia coming back. Read more

An ancient tumor in dogs might teach new tricks about cancer in people

Read more An ancient, sexually transmitted dog cancer has baffled researchers until now. Canine transmissible venereal tumor, CTVT, spreads when cancer cells move from one dog to another during sexual contact. By comparing the genomes of 186 healthy dogs to two of the dog tumor genomes, NHGRI researchers discovered genetic mutations that prevented the dogs' immune systems from detecting and fending off invading cancer cells. Findings were reported in the July 31, 2015 journal, Genome Research. Read more

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Undiagnosed Diseases Network launches online application portal

Read moreThe Undiagnosed Diseases Network (UDN), a clinical research initiative of the National Institutes of Health (NIH), has opened an online patient application portal called the UDN Gateway. Introduction of this application system sets the stage for the network to advance its core mission: to diagnose patients who suffer from conditions that even skilled physicians have been unable to diagnose despite extensive clinical investigation. Read more

Intramural trainees represent NHGRI at 2015 plain language competition

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NHGRI intramural trainees and representatives from other NIH institutes recently participated in a high-energy science communications contest called the Three-minute Talk (TmT). Five NHGRI intramural trainees competed as finalists, taking on the challenge to use plain language and one Powerpoint slide to explain their research in three-minutes or less. Talks by Dr. Gustavo Sudre (right) and Dr. Melissa Harris placed second and third. Read more

Last Updated: October 13, 2015