Research at NHGRI
The Division of Intramural Research conducts a broad program of laboratory and clinical research.
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The skin microbiome: More than skin deep

Red more Skin microbiota plays an intricate role in the human immune system, directing many immune functions and defending against invading bacterial pathogens. In a review article in the Nov. 21, 2014, issue of Science, Julie Segre, Ph.D., Head of the Microbial Genomics Section at NHGRI, and Yasmine Belkaid, Ph.D., head of the Mucosal Immunology Section at NIAID, review the advantages and downsides, of this intimate partnership. Read more.

Baylor College of Medicine, Medical College of Wisconsin to conduct DNA sequencing for Undiagnosed Diseases Network

Red more The National Institutes of Health (NIH) announced today that Baylor College of Medicine in Houston and the Medical College of Wisconsin in Milwaukee will be providing DNA sequencing for the Undiagnosed Diseases Network (UDN).  Each site will receive more than $2.5 million over four-years, pending availability of funds. Read more

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Tenure Track Job Positions at DIR

Multiple Investigator Recruitments in Genomics
October 6, 2014


NIH researchers publish comprehensive taxonomy and genetic analysis of skin microbial diversity

Read moreA team led by Julie Segre, Ph.D., chief of NHGRI's Translational and Functional Genomics Branch and Heidi Kong, M.D.,  investigator in the dermatology branch of the National Cancer Institute's Center for Cancer Research, produced an article published in the Oct. 2, 2014 issue of Nature reporting on their study of the genetic content of bacteria, viruses, fungi and other microorganisms on the skin of healthy individuals.  The authors performed DNA sequencing of the collection of genomes, or metagenome, of 18 sampling sites across the skin, revealing that each individual has a unique skin microbiota. Their analysis also demonstrated variation in the metagenome across the microenvironments of different body sites. According to the authors, the study is foundational for human disease studies investigating microbial interactions, metabolic changes and strain tracking, and defines the dual influence of biogeography and individuality on microbial composition and function. Read more

NIH scientists help identify genetic variants linked to glaucoma

August 31 Advance Online Publication of Nature Members of the Statistical Genetics Section of the National Human Genome Research Institute's Division of Intramural Research are co-authors of a study in the Aug. 31, 2014, advance online edition of Nature Genetics. In "Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma," researchers combined genetic data from 18 populations, including people of Asian and European descent, and identify ABCA1 as a risk gene for both high inner eye pressure and glaucoma. Read the study: Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma

Last Updated: November 20, 2014