Researchers have discovered a new genetic association and innovative way of identifying genes involved in coronary artery calcification, a leading cause of heart disease and death. The team led by the National Human Genome Research Institute used a combination of RNA, DNA and protein analysis to identify the gene, TREML4. They learned about its biological role in the condition and demonstrated an alternative approach to large genome-wide association studies for discovering disease-associated genes. Their paper, "Integrative DNA, RNA, and Protein Evidence Connects TREML4 to Coronary Artery Calcification," appeared in the July 3, 2014, online issue of the American Journal of Human Genetics.
Read the study: Integrative DNA, RNA, and Protein Evidence Connects TREML4 to Coronary Artery Calcification
In a new study in the April 10, online issue of Cell, NIH scientists, including NHGRI's Pamela Schwartzberg, M.D., Ph.D., describe an approach to modeling and predicting human immune responses to influenza vaccination based on the state of the immune system before immunization. The findings provide a framework for identifying factors that influence people's immune responses, which potentially may be used to optimize treatment. Read the study: Global analyses of human immune variation reveal baseline predictors of the post-vaccination response
Last Updated: June 24, 2014