Research at NHGRI
The Division of Intramural Research conducts a broad program of laboratory and clinical research.
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Baylor College of Medicine, Medical College of Wisconsin to conduct DNA sequencing for Undiagnosed Diseases Network

UDN map The National Institutes of Health (NIH) announced today that Baylor College of Medicine in Houston and the Medical College of Wisconsin in Milwaukee will be providing DNA sequencing for the Undiagnosed Diseases Network (UDN).  Each site will receive more than $2.5 million over four-years, pending availability of funds. Read more


NHGRI study uses social media to recruit

Read moreResearchers from NHGRI's Social and Behavioral Research Branch are using the power of social media and mobile phones to study what people around the world think about the intersections between genomics, genetics and society, as a part of the Social Genomics Project. The three-year project is comprised of seven surveys that ask questions about health risks, the flow of health information among family and friends, the use of genomic information to make important life and health decisions, as well as ancestry and race. Read more



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NHGRI Intramural Research Award

Learn about the 2013 awardees for the NHGRI Intramural Research Award 


Highlights

NIH scientists help identify genetic variants linked to glaucoma

August 31 Advance Online Publication of Nature Members of the Statistical Genetics Section of the National Human Genome Research Institute's Division of Intramural Research are co-authors of a study in the Aug. 31, 2014, advance online edition of Nature Genetics. In "Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma," researchers combined genetic data from 18 populations, including people of Asian and European descent, and identify ABCA1 as a risk gene for both high inner eye pressure and glaucoma. Glaucoma is a group of eye disorders that cause progressive damage to the optic nerve and can lead to permanent blindness. They also identified a link between two other genetic variants and both of these conditions.
Read the study: Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma


NHGRI-led study uses innovative method to find a gene associated with coronary artery calcification

July 3 issue of CellResearchers have discovered a new genetic association and innovative way of identifying genes involved in coronary artery calcification, a leading cause of heart disease and death. The team led by the National Human Genome Research Institute used a combination of RNA, DNA and protein analysis to identify the gene, TREML4. They learned about its biological role in the condition and demonstrated an alternative approach to large genome-wide association studies for discovering disease-associated genes. Their paper, "Integrative DNA, RNA, and Protein Evidence Connects TREML4 to Coronary Artery Calcification," appeared in the July 3, 2014, online issue of the American Journal of Human Genetics.
Read the study: Integrative DNA, RNA, and Protein Evidence Connects TREML4 to Coronary Artery Calcification


Last Updated: September 29, 2014