Research at NHGRI
The Division of Intramural Research conducts a broad program of laboratory and clinical research.
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NIH researchers tackle thorny side of gene therapy

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Bethesda, Md., Tues., Jan. 20, 2015 - National Institutes of Health researchers have uncovered a key factor in understanding the elevated cancer risk associated with gene therapy. They conducted research on mice with a rare disease similar to one in humans, hoping their findings may eventually help improve gene therapy for humans. Researchers at the National Human Genome Research Institute (NHGRI), part of NIH, published their research in the Jan. 20, 2015, online issue of the Journal of Clinical Investigation. Read more


NHGRI/Smithsonian collaboration to sequence North America's oldest dog relics

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When Smithsonian archeologist Dr. Daniel Stanford attended a talk on canine (dog) genomics by NHGRI's Dr. Elaine Ostrander, he realized the potential of the NMNH collection of ancient dog bones to canine genome research. With new sequencing tools and techniques now available - and the complete sequence of the dog genome - both hope to unlock the secrets of this ancient dog DNA, perhaps the oldest in North America. Read more


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Tenure Track Job Positions at DIR

Multiple Investigator Recruitments in Genomics
October 6, 2014


Highlights

NIH researchers publish comprehensive taxonomy and genetic analysis of skin microbial diversity

Read moreA team led by Julie Segre, Ph.D., chief of NHGRI's Translational and Functional Genomics Branch and Heidi Kong, M.D., investigator in the dermatology branch of the National Cancer Institute's Center for Cancer Research, produced an article published in the Oct. 2, 2014 issue of Nature reporting on their study of the genetic content of bacteria, viruses, fungi and other microorganisms on the skin of healthy individuals. The authors performed DNA sequencing of the collection of genomes, or metagenome, of 18 sampling sites across the skin, revealing that each individual has a unique skin microbiota.Read more


NIH scientists help identify genetic variants linked to glaucoma

August 31 Advance Online Publication of Nature Members of the Statistical Genetics Section of the National Human Genome Research Institute's Division of Intramural Research are co-authors of a study in the Aug. 31, 2014, advance online edition of Nature Genetics. In "Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma," researchers combined genetic data from 18 populations, including people of Asian and European descent, and identify ABCA1 as a risk gene for both high inner eye pressure and glaucoma. Read the study: Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma


Last Updated: January5, 2015