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News Release
How well cancer patients fare after chemotherapy can be affected by their social interaction with other patients during treatment.
… Jeannine Mjoseth … How well cancer patients fare after chemotherapy can be affected by … Institutes of Health, and the University of Oxford in the United Kingdom. … Cancer patients were a little more … moves more towards targeted therapies based on genomic tumor assessments, NHGRI is interested in understanding how …
News Release
A repurposed cancer drug appears to reduce the severity of lesions and pain experienced by people with Proteus syndrome
… Jeannine Mjoseth … A repurposed cancer drug appears to reduce the severity of lesions and … disease. The drug, miransertib, was well tolerated, even in children, according to a National Institutes of Health … and collaborators published the findings Feb. 21, 2019, in the American Journal of Human Genetics . … "We discovered …
Fact Sheets
A DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes.
… The DNA microarray is a tool used to determine whether the DNA from a particular individual contains a mutation in genes. … Scientists know that a mutation - or alteration - … with a particular mutation actually develop breast cancer, or to identify the changes in gene sequences that are …
Fact Sheets
DNA sequencing determines the order of the four chemical building blocks - called "bases" - that make up the DNA molecule.
… DNA sequencing determines the order of the four chemical … scientists the kind of genetic information that is carried in a particular DNA segment. For example, scientists can use … to use sequencing to detect and treat some diseases. In cancer, for example, physicians are increasingly able to use …
Research at NHGRI
The NHGRI Cancer Genetics and Comparative Genomics Branch identifies and study genes that contribute to cancer susceptibility and progression.
… accumulate over time. Some of these genomic changes drive tumor initiation, growth and metastases, while others are … tumorigenesis. They search for causal sequence variants in DNA from inherited cells of at-risk individuals, in human …
Talking Glossary
A cancer-susceptibility gene is a gene that, when changed (or mutated), gives an individual an increased risk for developing cancer
… Cancer-Susceptibility Gene … A cancer-susceptibility gene is … cancer. Individuals who have inherited mutations in certain cancer-susceptibility genes have a lifetime risk … the general population (e.g., BRCA1 / BRCA2 ). Individuals in the high-risk category may benefit from more frequent …
Educational Resources
Recombinant DNA Technology is a technology that uses enzymes to cut and paste together DNA sequences of interest.
… Recombinant DNA Technology … Recombinant DNA Technology is a technology that uses enzymes to cut and … work typically involves propagating the recombinant DNA in a bacterial or yeast cell, whose cellular machinery copies …
Educational Resources
Mitochondrial DNA is the small circular chromosome found inside mitochondria.
… Mitochondrial DNA … Mitochondrial DNA is the small circular chromosome found inside … the cellular organelles called mitochondria. Located in the cytoplasm, mitochondria are the site of the cell’s …
Educational Resources
DNA fingerprinting is a laboratory technique used to establish a link between biological evidence and a suspect in a criminal investigation.
… DNA Fingerprinting … DNA fingerprinting is a laboratory technique used to … establish a link between biological evidence and a suspect in a criminal investigation. … DNA Fingerprinting, Criminal … that are unique to individuals. DNA fingerprinting is used in a variety of situations, such as criminal investigations, …
Talking Glossary
La hibridación in situ es una técnica de laboratorio empleada para localizar una secuencia de ADN o ARN en una muestra biológica.
… Hibridación in situ … La hibridación in situ es una técnica de … is a laboratory technique used to localize a sequence of DNA or RNA in a biological sample. In this technique, a … then exposed to a “probe”—a small piece of single-stranded DNA tagged with a chemical or fluorescent dye. The labeled …