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News Release
NHGRI convened geneticists, biologists, clinicians, bioinformatics specialists and more to provide expert advice on the future of its Genome Sequencing Program.
… into the clinic. In addition to the long-established Large-Scale Sequencing and Analysis Center (LSAC) program, the GSP … This means supporting research into new DNA sequencing methods and data analysis techniques and solving difficult …
Fact Sheet
Genomic variation accounts for some of the differences among people, including important aspects of their health and susceptibility to diseases.
… in human genomes, ranging from small differences to large differences.  A very small subset of genomic variants … of new experimental technologies and data-analysis methods. Such advances are readily applicable to ongoing … of nucleotides to larger chromosomal regions. These large-scale genomic differences are called structural …
Staff
Dr. Meru Sadhu is the head of the Systems Biology and Genome Engineering Section at the National Human Genome Research Institute. ​
… to understand host range comprehensively, harnessing large-scale DNA synthesis technology and high-throughput yeast screening. Long term, our goal is to leverage this … Engineering Section, where he is using high-throughput methods to address important questions in genetics.  SBGE …
Fact Sheets
Genetics refers to the study of genes and their roles in inheritance. Genomics refers to the study of all of a person's genes (the genome).
… for some complex diseases, as well as new diagnostic methods. … anemia and cystic fibrosis are inherited in families, what screening and testing options are available, and, for some … genes in a person or other organism. Due to the success of large-scale biology projects such as the sequencing of the …
Staff
Dr. Wilson is the co-chief of and senior investigator in NHGRI's Computational and Statistical Genomics Branch.
… of the statistical properties of newly developed methods of genetic analysis for quantitative traits. … for sequence variants (tiled regression). In addition, the large and small sample statistical properties of these tests … (millions), e.g. high density SNP panels, and/or large-scale sequencing producing large numbers of rare sequence …
Research Funding
Building upon a foundation of quantitative genetics laid over a century ago, applying modern genomic approaches to resolve how genetic and non-genetic factors shape variation in human diseases and traits.
… variation. These issues have recently risen to the fore as large-scale genome-wide association studies (GWAS) reveal … human traits. Fortunately, the growing availability of large-scale human genetic, genomic, and phenotypic data … Developing Novel Theory and Methods for Understanding the Genetic Architecture of Complex …
News Release
Researchers with support from NIH will conduct research into the genetic underpinnings of Alzheimer's disease.
… for using innovative new technologies and computational methods for the analysis. The scientists also will seek … the disorder. They also will study genomic data from 111 large families, a portion of which are of Caribbean Hispanic … goals, the grantees will collaborate with the NHGRI Large-Scale Sequencing and Analysis Centers program, an …
News Release
NHGRI researchers will present four platform talks and 55 posters to highlight the institute's diverse portfolio at the 65th annual meeting of ASHG.
… the presidential symposium titled, Genetic Epidemiology at Scale: High Throughput Genomics Linked to Large Scale HER Systems . National Institutes of Health (NIH) … M Sorant: Evaluation of stepwise and penalized regression methods in selecting a set of genetic predictors explaining …
Funding Opportunities
Funding Opportunities for Investigator-Initiated Research in Computational Genomics and Data Science
The Computational Genomics and Data Science Program Announcements (PARs) invite applications for investigator-initiated research efforts fostering innovation in computational genomics, data science, statistics, bioinformatics, and data visualization and exploration.
… S UNIVERSITY OF CALIFORNIA BERKELEY Scalable Computational Methods for Genealogical Inference: from species level to … Annotation of Genomes via Phenotypic Convergence within Large Multi-species Alignments HG009299 JI, HONGKAI JOHNS … NATHAN UNIVERSITY OF VIRGINIA Novel methods for large-scale genomic interval comparison HG012558  LANGMEAD, …
Event
On November 16-17, 2023, the National Human Genome Institute will co-sponsor a workshop, Advances in the Genetic Architecture of Complex Human Traits, to take a historically grounded and forward-looking approach towards dissecting the genetic architecture of complex traits in humans.
… traits?  Advances in sequencing technologies and optical methods allow us to profile the molecular features of cells at scale. What’s needed, technically or theoretically, for … variables in genetic studies?  There are currently large efforts to diversify the demographics of genetic …