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News Release
Stomach cancers fall into four distinct molecular subtypes researchers with The Cancer Genome Atlas Network have found.
… with The Cancer Genome Atlas (TCGA) Network have found. In the study, published online July 23, 2014, in Nature , the … cells can look under a microscope, even when from the same tumor. The researchers hope that the new classification … They used six molecular analysis platforms including DNA sequencing, RNA sequencing, and protein arrays. Tumors in …
News Release
A the largest genomics study of clear cell endometrial cancer (CCEC) tumors has identified mutations in the TAF1 gene.
… NHGRI Communications and Public Liaison Branch … In the largest genomics study of clear cell endometrial … Darryl Leja, NHGRI.  Dr. Bell and her team isolated DNA from tumor cells and from normal cells from patients with CCEC. …
Media Availability
The Cancer Genome Atlas identified molecular subtypes to help clinicians determine which tumors are more aggressive and which will respond to treatment.
… thyroid carcinomas (PTC) - the most common form of thyroid cancer - has provided new insights into the roles of … confirmed that PTCs are driven primarily by mutations in one of two cancer-associated genes: BRAF (and a particular … types, particularly in signaling pathways that promote tumor development and growth. The researchers developed a …
Media Availability
TCGA researchers have found that chromophobe renal cell carcinoma stems partly from gene alterations in the mitochondria, the cell's energy supplier.
… Steven Benowitz … Media Availability Researchers in The Cancer Genome Atlas (TCGA) Network have made a number … the cell's energy supplier. They also discovered that the tumor is characterized by genetic rearrangements near a gene important in DNA repair and in maintaining telomerase, the enzyme which …
Genetic Disorders
Breast cancer is the second most common cancer in women after skin cancer.
… Breast cancer is the second most common cancer in women after skin … the gene mutation. … In 1995 and 1996, studies of DNA samples revealed that Ashkenazi (Eastern European) Jews …
News Release
NHGRI researchers have identified a genomic signature for some aggressive prostate tumors, which may help healthcare providers pinpoint treatment options.
… Mjoseth … A key challenge health care providers face in treating prostate cancer is distinguishing the aggressive, … cancerous by producing proteins that fix damage to DNA. The research team used whole genome sequencing, a … DNA make-up of an organism at a single time, to look at tumor-specific mutations in aggressive prostate cancer. The …
Genetic Disorders
Skin cancer is the most common type of cancer in the United States.
… Skin cancer is the most common type of cancer in the United States. An estimated 40 to 50 percent of … booths, also play a role. UV radiation can damage the DNA, or genetic information, in skin cells, creating … can be cured if it is diagnosed and treated when the tumor has not deeply invaded the skin. However, if a melanoma …
News Release
The TCGA network describes uterine and bile duct cancer.
… of Breast Cancer The TCGA data, more than two petabytes in total from 33 cancer types, catalogs all the key genomic changes - the modifications in DNA, RNA and proteins that cause the uncontrolled cell growth … by healthy cells (in pink), illustrating a primary tumor spreading to other parts of the body through the …
News Release
Investigators with The Cancer Genome Atlas Research Network have identified new potential therapeutic targets for a major form of bladder cancer.
… including important genes and pathways that are disrupted in the disease. They also discovered that, at the molecular … therapy based on the characteristics of each patient's tumor." "The real excitement about this project is that we … treat form of bladder cancer." The research team analyzed DNA, RNA and protein data generated from the study of 131 …
Talking Glossary
El cáncer es una enfermedad en la que algunas células del cuerpo crecen fuera de control. Hay muchos tipos diferentes de cáncer, y cada uno comienza cuando una única célula adquiere un cambio genómico (o mutación) que le permite dividirse y multiplicarse sin control.
… que le permite dividirse y multiplicarse sin control. … Cancer is a disease in which some of the body’s cells grow uncontrollably. There … other sites. Such mutations can be caused by errors during DNA replication or result from DNA damage due to …